IL-17与肝脏疾病的相关性

Research advances in the association between interleukin-17 and liver diseases

IL-17是辅助性T淋巴细胞17产生的一种促炎因子。IL-17可诱导多种趋化因子参与机体的免疫调节和炎症反应。IL-17通过激活肝脏内多种细胞产生炎性介质,分泌多种促炎因子调控肝脏的炎症。IL-17在多种肝脏疾病中的表达增高,如病毒性肝病、脂肪性肝病、自身免疫性肝病、肝寄生虫感染,并可促进肝硬化和肝癌的发生发展,与肝功能衰竭、肝移植排斥反应相关。综述了近年IL-17在肝脏疾病中的相关研究及进展。

Interleukin-17（ IL-17） is a proinflammatory factor produced by T helper 17 cells and can induce a variety of chemokines which participate in the body＇s immunoregulation and inflammatory response. IL-17 can activate various liver cells to produce inflammatory mediators and secrete proinflammatory factors and thus regulate liver inflammation. IL-17 is upregulated in many liver diseases,such as virus hepatitis,fatty liver disease,autoimmune liver diseases,and parasite infection in the liver,and it can promote the development and progression of liver cirrhosis and liver cancer and is associated with liver failure and rejection reaction in liver transplantation. This article reviews the research advances in the role of IL-17 in liver diseases.