系统性红斑狼疮患者血脂与炎症因子相关性研究

Correlation between serum lipids and inflammatory factors in patients with systemic lupus erythematosus

目的探究系统性红斑狼疮(SLE)患者血脂水平与炎症因子的相关性。方法收集2016年9月至2017年2月郑州大学第一附属医院收治的100例SLE患者,将SLE患者根据血脂是否异常分为血脂正常组(56例)与血脂异常组(44例),回顾性分析血脂水平,检测SLE患者甘油三脂(TG)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、补体(C3、C4)、血沉(ESR)、C反应蛋白(CRP)水平。采用SPSS 17.0统计学软件对SLE患者的血脂水平与其炎症因子进行相关性分析。结果血脂异常组CRP较血脂正常组高;TG与C3呈负相关,与CRP呈正相关;HDL与C3呈正相关。结论 SLE患者血脂异常与炎症因子具有相关性,但炎症因子不是血脂异常的独立危险因素。

Objective To explore the correlation between serum lipid level and inflammatory factors in patients with systemic lupus erythematosus. Methods One hundred SLE patients from the First Affiliated Hospital of Zhengzhou University were col- lected and divided into nmlnal lipid group （56 cases） and dyslipidemia group （44 cases） according to whether the blood lipid was abnormal, and the level of blood lipid was analyzed retrospectively. Triglyeeride （TG）, high density lipoprotein （HDL）, low density lipoprotein （LDL）, C3, C4, ESR, CRP were detected in patients with SLE. Correlation analysis was performed by using SPSS 17.0 statistical software for blood lipid levels and inflammatory factors in SLE patients. Results The level of CRP in dyslipidemia group was higher than that in normal blood lipid group. TG was negatively correlated with C3 and positively correla- ted with CRP. HDL was positively correlated with C3. Conclusion Dyslipidemia is associated with inflammatory factors in SLE patients, but not the independent risk factor of inflammatory factors of dyslipidemia.