类风湿因子和抗环瓜氨酸肽抗体在老年类风湿关节炎患者中的临床意义研究

The value of rheumatoid factor and anti-cyclic citrullinated peptide antibody in elderly patients with rheumatoid arthritis

目的探究类风湿因子(RF)和抗环瓜氨酸肽抗体(抗-CCP)在老年类风湿关节炎(RA)患者中的临床研究意义。方法选取2014年4月至2016年8月该院收治的老年RA患者100例,将其作为研究对象。另取健康人群50例,作为对照组。对两组体内RF和抗-CCP进行检测,分析这两项指标在RA患者血液中是否存在差异。结果研究组中RF阳性为75例,占75%,即灵敏度为75%;对照组中有7例,占14%,特异性为86%,高于研究组的75%,两组相比差异有统计学意义(P<0.05);研究组中抗-CCP抗体阳性有69例,占69%,即灵敏度为69%;对照组中为3例,占6%,即特异度为94%远高于对照组的69%,差异有统计学意义(P<0.05)。对两组实验中RF与抗-CCP指标水平的比较,研究组即RA患者的两项指标水平均远远高于对照组。结论 RF相对于抗-CCP灵敏度较高,但特异度较低,RF和抗-CCP联合检测更有利于提高灵敏度及特异性。

Objective To investigate the clinical significance of rheumatoid factor（RF）and anti-cyclic citrullinated peptide antibody（anti-CCP）in elderly patients with rheumatoid arthritis（RA）.Methods 100 elderly patients with rheumatoid arthritis treated in the First Affiliated Hospital of Jilin University from April 2014 to August 2016 were randomly selected as the subjects.Another 50 healthy people were randomly selected as the control group.The rheumatoid factor（RF）and anti-cyclic citrullinated peptide antibody（anti-CCP）were measured in the two groups,and the RF and aanti-CCP were analyzed in patients with rheumatoid arthritis The rheumatoid factor（RF）was detected by the turbidimetric method,and the anti-cyclic citrullinated peptide antibody（anti-CCP）was detected by enzyme-linked immunosorbent assay（ELISA）.Results In the research group,there were 75 RF positive cases（75%）,and 7cases（14%）in the control group,the specificity was 86%.There were 69anti-CCP positive cases（69%）in the research group,69%（69%）and 3cases（6%）in the control group,the specificity was 94%.Compared the contents of RF and anti-CP of the two groups,the content of the two indexes in the RA group were much higher than those in the control group.Conclusion Rheumatoid factor（RF）is more sensitive than anti-citrullinated peptide antibody（anti-CCP）,but it has poor specificity.It can be seen from this experiment that combined detection of RF and anti-CCP is more sensitive and specificity.