药物治疗胃溃疡疗效、安全性及药物经济学评价

Efficacy, Safety and Pharmacoeconomic Evaluation of Drug Therapy for Gastric Ulcer

目的对泮托拉唑和奥美拉唑治疗胃溃疡的效果以及药物经济学进行分析评价。方法研究样本为68例胃溃疡患者,随机分为两组,A组行泮托拉唑治疗,B组行奥美拉唑治疗,对治疗效果、不良反应以及药物经济学进行分析评价。结果 A组患者的治疗有效率为91.18%,B组为94.12%,组间对比,差异无统计学意义(P>0.05);A组中2例(5.88%)患者出现恶心呕吐;B组中有3例(8.82%),组间对比,差异无统计学意义(P>0.05);A组C/E值为22.85;B组C/E值为33.47,组间对比,差异具有统计学意义(P<0.05)。结论采用泮托拉唑治疗胃溃疡效果明显,患者不良反应低且药物更为经济。

Objective The effect of pantoprazole and omeprazole on gastric ulcer and drug economics were analyzed and evaluated. Methods The study sample consisted of 68 patients with gastric ulcer, who were randomly divided into two groups, group A was treated with pantoprazole, group B was treated with omeprazole. The therapeutic effects, adverse reactions and pharmacoeconomics were analyzed and evaluated. Results The effective rate of group A was 91.18%, and that of group B was 94.12%. There was no significant difference between the two groups （P 〉 0.05）. There were 2 cases （5.88%） with nausea and vomiting in group A. There were 3 cases （8.82%） in group B, and there was no significant difference between groups （P 〉 0.05）. The C/E value of group A was 22.85, the value of C/E in group B was 33.47, and the difference between groups was statistically significant （P 〈 0.05）. Conclusion The use of pantoprazole in the treatment of gastric ulcer effect is obvious, the patient is low and the drug is more economical.