乳酸左氧氟沙星与甲硝唑在慢性盆腔炎中的临床疗效

Clinical Efficacy of Levofloxacin Lactate and Metronidazole in Chronic Pelvic Inflammatory Disease

目的观察慢性盆腔炎经乳酸左氧氟沙星联合甲硝唑注射液治疗的临床效果。方法选择来我院就诊的慢性盆腔炎患者200例作为研究对象。采用随机均等法,将其分为对照组(100例)和观察组(100例)。对照组采用左氧氟沙星治疗,观察组采用左氧氟沙星+甲硝唑治疗,比较两组患者的治疗结果差异。结果观察组的治疗有效率为95.0%,不良反应发生率14.0%;对照组分别为85.0%、11.0%,观察组的治疗有效率高于对照组,差异具有统计学意义(P<0.05);经治疗后,观察组的超敏C反应蛋白(hs-CRP)、白介素6(IL-6)、肿瘤坏死因子(TNF-α)等炎症指标水平均低于对照组,差异具有统计学意义(P<0.05);对照组的不良反应发生率,与观察组比较,差异无统计学意义(P>0.05)。结论在慢性盆腔炎的治疗中将乳酸左氧氟沙星与甲硝唑联合使用可取得更显著的治疗效果,且不增加药物不良反应。

Objective To observe the clinical effect of levofloxacin lactate combined with metronidazole injection in chronic pelvic inflammatory disease. Methods 200 cases of chronic pelvic inflammatory disease in our hospital were selected as the study objects. The patients were divided into the control group （100 cases） and the observation group （100 cases） by random equal method. The control group was treated with levofloxacin, the observation group was treated with levofloxacin plus metronidazole, the treatment outcome difference between the two groups was compared. Results The effective rate of the treatment group was 95.0%, the incidence of adverse reactions was !4.0%, the control group were 85.0% and 11.0% respectively. The effective rate of the treatment group was higher than that of the control group, the difference was statistically significant （P〈0.05）. After treatment, the levels of hypersensitivity C reactive protein （hs-CRP）, interleukin 6 （IL-6） and tumor necrosis factor （TNF-α） in the observation group were lower than those in the control group, the difference was statistically significant （P 〈 0.05）; There was no significant difference in the incidence of adverse reactions between the control group and the observation group （P 〉 0.05）. Conclusion Levofloxacin lactate combined with metronidazole in the treatment of chronic pelvic inflammatory disease can achieve a more significant therapeutic effect without increasing adverse drug reactions.