不同剂量孕激素治疗月经失调(无排卵型)的效果分析

Analysis of the Effect of Different Doses of Progesterone on Menstrual Disorders(Anovulation)

目的探讨不同剂量孕激素治疗月经失调(无排卵型)的临床效果与不良反应。方法选取2015年4月—2017年4月我院收治的无排卵型月经失调患者150例作为研究对象。在患者签署知情同意书的情况下,采用随机对照组的方法分为3个组,每组各50例患者,分别给予每日100 mg、200 mg、300 mg三种剂量的黄体酮治疗,观察三组患者的临床效果。结果低剂量组患者临床有效率为88%,中剂量组临床有效率为90%,高剂量组临床有效率为92%,虽然随着剂量的增加,患者临床有效率呈现上升趋势,但是三组患者临床有效率比较,差异无统计学意义(P>0.05)。低剂量组患者的不良反应发生率为4%,中剂量组患者的不良反应发生率为12%,高剂量组患者的不良反应发生率为24%,随着剂量的增加,患者的不良反应发生率呈现上升趋势,三组患者不良反应发生率对比,差异具有统计学意义(P<0.05)。结论每日100 mg、200 mg、300 mg三种剂量的黄体酮治疗无排卵型的月经失调,临床效果相当,但是剂量越大不良反应越大,临床推荐从小剂量开始使用。

Objective To investigate the clinical effect and adverse reactions.of different doses of progesterone in the treatment of menstrual disorders （anovulation）. Methods 150 patients with anovulatory menstrual disorders from April 2015 to April 2017 were selected as the subjects. In the case of informed consent, the patients were divided into three groups according to the method of randomized control group. 50 cases were given daily 100 mg, 200 mg, 300 mg three doses of progesterone treatment, to observe the clinical effect. Results The clinical effective rate was 88% in low dose group, the clinical effective rate was 90% in medium dose group, and 92% in high dose group. Although with the increase of dosage, the clinical efficiency of patients showed an upward trend. However, there was no significant difference in the clinical efficiency between the three groups （P 〉 0.05）. The adverse reaction rate in the low-dose group was 4%, and the adverse reaction rate was 12% in the middle dose group, and the adverse reaction rate was 24% in the high dose group. With the increase of dosage, the incidence of adverse reactions in patients showed an upward trend. The incidence of adverse reactions in the three groups was statistically significant （P 〈 0.05）. Conclusion 100 mg, 200 mg, 300 mg three doses of progesterone treatment of anovulatory menstrual disorders, the clinical effect is equivalent, but the greater the dose the greater the adverse reactions, clinical recommended from the small dose began to use.