三模块治疗高龄肌层浸润性膀胱癌临床疗效观察

Effects of three-module therapy in treatment of MIBC in senile patients

目的探讨三模块治疗高龄肌层浸润性膀胱癌的临床疗效。方法对医院收治的高龄肌层浸润性膀胱癌,并进行了保留膀胱三模块治疗的53例患者临床资料进行回顾性分析,探讨三模块治疗高龄肌层浸润性膀胱癌的临床疗效。结果本组53例中,有26例(49.1%)在治疗过程中,未出现排尿困难、肠炎等并发症,能完成三模块整个治疗过程。有36例随访3年,其中21例(58.3%)无复发及转移,12例(33.3%)再次行三模块治疗,3例(8.3%)因脏器功能衰竭死亡;17例随访5年,4例(23.5%)无复发和转移,7例(41.1%)再次行三模块治疗,6例(35.3%)因脏器功能衰竭死亡。结论保留膀胱的三模块治疗高龄浸润性膀胱癌,可避免根治行膀胱切除术的众多并发症,有利于提高患者生活质量,同时可有效控制肿瘤的进展,是一种可供选择的合理治疗方案。

Objective To explore the effects of three-module therapy in the treatment of muscle-invasive bladder cancer （MIBC） in senile patients. MeAods The clinical data of a total of 53 senile patients with MIBC who had been admitted to our hospital and has received bladder-preserving three-module treatment were analyzed retrospectively to explore the effects of three-module therapy in the treatment of MIBC in senile patients. RMults Among the 53 patients in the group, 26 patients （49.1%） had no complications, such as difficulty in urination and enteritis, and could complete the whole process of three-module treatment. During the three-year follow-up visit, among the 36 patients, 21 patients （58.3%） had no recurrence or metastasis, 12 ones （33.3%） received another three- module treatment, and three ones （8.3%） died of organ failure; during the five-year follow-up visit, among the 17 patients, four patients （23.5%） had no recurrence or metastasis, seven ones （41.1%） received another three-module treatment and six ones （35.3%） died of organ failure. Conclusion The ladder-preserving three-module therapy in the treatment of MIBC in senile patients can avoid the complications after radical cystectomy, is beneficial to improve the quality of life of patients, can effectively control tumor progression and is an alternative reasonable therapeutic regimen.