柴胡龙骨牡蛎汤治疗老年女性精神分裂症的疗效分析

Effects of Chaihulonggumuli Decoction in treatment of schizophrenia in senile female patients

目的观察柴胡加龙骨牡蛎汤联合西药治疗老年女性精神分裂症的临床疗效及对相关细胞因子的影响。方法选取老年女性精神分裂症患者80例,随机分为2组,每组40例,研究组给予柴胡加龙骨牡蛎汤联合阿立哌唑治疗,对照组单纯使用阿立哌唑治疗,疗程为8 w。在治疗前及治疗后第2、4、8 w末,检测患者简明精神病评定量表(BPRS)、阳性症状评定量表(SAPS)和阴性症状评定量表(SANS)评分;采用酶联免疫吸附试验(ELISA)检测患者的血清IL-6、IL-8、TNF-α水平。结果治疗后,两组BPRS、SAPS、SANS评分随治疗时间的延长而呈逐渐下降趋势(P<0.01),但在各时间点研究组的评分均显著低于对照组(P<0.01);治疗8 w末,两组IL-6、IL-8、TNF-α水平较治疗前均显著降低(P<0.05),而研究组降低水平均显著大于对照组(P<0.05)。结论柴胡加龙骨牡蛎汤联合阿立哌唑可有效提高治疗老年女性精神分裂症的疗效,降低血清IL-6、IL-8、TNF-α水平可能为其作用机制之一。

Objective To observe the effects of Chaihulonggumuli Decoction combined ＂with Western medicine in the treatment of schizophrenia in senile female patients and the impacts on related cytokines. MeAods A total of 80 senile female patients with schizophrenia were selected and randomly divided into a study group and a control group （n=40, respectively）. The study group was treatment with Chaihulonggumuli Decoction combined with aripiprazole and the control group with aripiprazole. The course of treatment lasted for eight weeks. At the end of the second, fourth and eighth week before and after the treatment, the scores of brief psychiatric rating scale （BPRS）, the scale for the assessment of positive symptoms （SAPS） and the scale for the assessment of negative symptoms （SANS） in the patients were detected; enzyme linked immunosorbent assay （ELISA） was applied to detect the serum IL-6, IL-8 and TNF-琢 levels in patients. Results After the treatment, the BPRS, SAPS and SANS scores in the tw-o groups gradually decreased with the extension of treatment time^〉〈 0.01）, but the scores at each time points in the study group were significantly lower than those in the control group （P 〈 0.01）; at the end of eight weeks of treatment, the IL-6, IL-8 and TNF-琢 levels in the two groups were significantly lower than those before the treatment （P 〈 0.05）, while the decrease in the study group was greater than that in the control group （P 〈 0.05）. Condusion Chaihulonggumuli Decoction combined with aripiprazole can effectively improve the effects in the treatment of schizophrenia in senile female patients. The reduction of the levels of serum IL-6, IL-8 and TNF-琢 may be one of the mechanisms of action.