多功能超声分子探针显像与增效高强度聚焦超声治疗

Multifuctional ultrasound molecular probes for imaging and synergistic high-intensity focused ultrasound therapy

随着分子影像学的迅猛发展,单一功能的超声分子探针已不能满足日益增长的医学需求,多功能超声分子探针应运而生。多功能超声分子探针不仅可对活体状态下的生物过程进行细胞和分子水平的多种模式显示,还能在分子成像系统的监测下进行治疗,为疾病的早期发现、诊断及治疗打下坚实基础。高强度聚焦超声是近年发展迅速的典型无创治疗技术,能将高能量超声波聚焦至靶区部位,产生瞬态高温,消融肿瘤组织。但其在生物组织传播中会发生能量衰减,影响靶区能量沉积和消融效果,因此高强度聚焦超声增效剂的研究也十分必要。

With the rapid development of medical imaging,a single-functional ultrasound molecular probe has been unable to meet the increasing medical requirements,therefore,the multifunctional molecular probe has become an important object of investigation. The multifunctional ultrasound molecular probes can be served as not only multimodal imaging of cellular and molecular levels in biological processes in living creatures,but also for therapy under monitoring by molecular imaging systems,laying the foundation for early detection,diagnosis and treatment of disease. High-intensity focused ultrasound（HIFU）is a rapid developed,typical noninvasive therapy technology in recent years,which could focus and deposit ultrasonic energy in the target region,and then rapidly raise the tissue temperature inducing tumor ablation. However,ultrasonic energy attenuates exponentially with increasing depth in the tissue,which would affect the energy deposition and ablation effects,so it is necessary to investigate the HIFU synergistic agents.