慢性心衰患者氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白的变化情况分析

Analysis of Changes of Nt-probnp, Plasma Cardiac Troponin Ⅰ and hsCRP of Patients with Chronic Heart Failure

目的探讨慢性心衰患者氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白的变化情况。方法分析该院2016年1月—2017年1月收治的慢性心衰患者60例作为慢性心衰组,依据心功能分级又分为心功能Ⅱ级组18例、Ⅲ级组20例、Ⅳ级组22例,选取同期健康体检者50名作为对照组。观察对照组和慢性心衰组氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白情况;观察不同心功能组慢性心衰患者氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白情况;观察慢性心衰患者氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白和心功能相关性情况。结果心功能Ⅲ级组、心功能Ⅳ级组慢性心衰患者氨基末端脑钠肽前体(3 680.4±258.2)、(6 180.7±880.7)pg/m L、血浆肌钙蛋白Ⅰ(0.30±0.16)、(0.72±0.28)ng/m L、高敏C反应蛋白(22.8±3.6)mg/L、(32.3±5.2)mg/L均高于心功能Ⅱ级组(304.7±86.5)pg/m L、(0.15±0.02)ng/m L、(6.2±1.0)mg/L,心功能Ⅳ级组氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白均高于心功能Ⅲ级组,慢性心衰组氨基末端脑钠肽前体(295.4±40.2)pg/m L、血浆肌钙蛋白Ⅰ(0.6±0.4)ng/m L、高敏C反应蛋白(18.1±2.7)mg/L均高于对照组(118.7±18.6)pg/m L、(0.02±0.01)ng/m L、(3.8±0.5)mg/L,慢性心衰患者心功能分级和氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白呈现明显正相关性,差异有统计学意义(P<0.05)。结论慢性心衰患者病情进展和氨基末端脑钠肽前体、血浆肌钙蛋白Ⅰ、高敏C反应蛋白有着密切关系,可以为指导临床治疗提供可靠的理论依据。

Objective To discuss the changes of nt-probnp, plasma cardiac troponin Ⅰ and hs CRP of patients with chronic heart failure. Methods 60 cases of chronic heart failure patients in our hospital from January 2016 to January2017 were selected and divided into the group cardiac function Ⅱ level with 18 cases, Ⅲ level group with 20 cases and Ⅳ level with 22 cases, and 50 cases of healthy physical examination persons at the same period were selected as the control group, and the nt-probnp, plasma cardiac troponin Ⅰ and hs CRP of patients with chronic heart failure were observed. Results The nt-probnp, plasma cardiac troponin Ⅰ and hs CRP in the cardiac function Ⅲ level group and Ⅳlevel group were higher than those in the cardiac function Ⅱ level group, [(3680.4±258.2)pg/m L,(6180.7±880.7)pg/m L,(0.30±0.16)ng/m L,(0.72±0.28)ng/m L,(22.8±3.6)mg/L,(32.3±5.2)mg/L vs(304.7±86.5)pg/m L,(0.15±0.02)ng/m L,(6.2±1.0)mg/L], and the nt-probnp, plasma cardiac troponin Ⅰ and hs CRP in the cardiac function Ⅳ level group were higher than those in the cardiac function Ⅲ level group, and the nt-probnp, plasma cardiac troponin Ⅰ and hs CRP in the chronic heart failure group were higher than those in the control group, [(295.4 ±40.2)pg/m L,(0.6 ±0.4)ng/m L,(18.1±2.7)mg/L vs(118.7±18.6)pg/m L,(0.02±0.01)ng/m L,(3.8±0.5)mg/L], and the cardiac function classification had an obvious correlation with the nt-probnp, plasma cardiac troponin Ⅰ and hs CRP, and the difference was statistically significant(P<0.05). Conclusion The disease progress of chronic heart failure patients has a close relationship with the nt-probnp, plasma cardiac troponin Ⅰ and hs CRP, which can provide reliable theoretical basis for guiding the clinical treatment.