化疗、全反式维甲酸联合砷剂序贯治疗成人急性早幼粒细胞白血病疗效分析

Curative Effect Analysis of Chemotherapy and All Trans Retinoic Acid and Sequential Arsenic Agent for Treatment of Adult Acute Promyelocytic Leukemia

目的观察与探究化疗、全反式维甲酸联合砷剂序贯治疗成人急性早幼粒细胞白血病疗效。方法选取2011年1月—2013年1月期间于该院就诊及治疗的60例成人急性早幼粒细胞白血病患者作为研究对象,按照随机数字表法分为两组,每组各有30例患者,对对照组患者给予化疗与全反式维甲酸的交替治疗,对观察组患者给予化疗、全反式维甲酸联合砷剂的序贯治疗,对比并分析两组患者的疾病缓解率、3年内累积生存率、3年内复发率。结果观察组患者的疾病缓解率(80.00%)、3年内累积生存率(93.33%)、3年内复发率(13.33%)与对照组患者(56.67%、66.67%、50.00%)相对比,组间比较差异有统计学意义(P<0.05)。结论对成人急性早幼粒细胞白血病患者使用化疗、全反式维甲酸联合砷剂序贯治疗的效果较好。

Objective This paper tries to observe and explore the curative effect of chemotherapy, all trans retinoic acid and sequential arsenic agent for treatment of adult acute promyelocytic leukemia. Methods 60 cases of adult acute myelocytic leukemia patients from January 2011 to January 2013 in this hospital were selected, and divided into two groups according to random number table method with 30 cases in each group. The control group adopted chemotherapy and all trans retinoic acid treatment of alternation, the observation group adopted chemotherapy, all trans retinoic acid and sequential arsenic agent treatment, and then the disease mitigation rate, cumulative survival rate within 3 years, recurrence rate within 3 years of two groups of patients were compared and analyzed. Results The disease mitigation rate,cumulative survival rate within 3 years, recurrence rate within 3 years of the observation group were 80.00%, 93.33%,13.33% respectively, and those of the control group were 56.67%, 66.67%, 50.00%, so there was significant difference between groups（P0.05）. Conclusion Chemotherapy, all trans retinoic acid and sequential arsenic agent therapy on the treatment of adult acute promyelocytic leukemia is effective.