酒精对KM小鼠口腔颊黏膜阿弗他溃疡的影响

Alcohol Influences on Recurrent Aphthous Ulcer of KM Mice Buccal Mucosa

目的通过观察酒精刺激KM小鼠口腔黏膜溃疡面所产生的效果与生理性反应,探究酒精与口腔阿弗他溃疡的相关联系。方法使用苯酚灼烧KM小鼠颊黏膜制作阿弗他溃疡模型。将小鼠随机分为5组,用不同浓度酒精处理溃疡面。于48 h、72 h观察溃疡面的愈合情况。结果 48 h,E组溃疡愈合情况较好。72 h,A组、B组溃疡愈合情况较好。结论低浓度酒精(浓度≤15%)需较长作用时间(48~72 h)方能有效促进溃疡面的愈合;高浓度酒精(浓度≥75%)短期作用(24~48 h)亦能促进溃疡面的愈合;高浓度酒精的作用超过72 h则易刺激黏膜组织,产生反效果。

Objective To find out the links between alcohol and recurrent aphthous ulcer by observing the influences and physiological responses of the stimulation of KM mice oral ulcers with alcohol. Methods The model of recurrent aphthous ulcers were constructed by cauterizing with paphenol. The mice were randomly divided into 5 groups by different alcohol concentrations. The ulcer sizes were summed on the third and fifth day in order to study the alcohol effects of healing. Results 48 hours, the healing situation of E group are better than the other groups. 72 hours, A and B group's ethanol ulcer healing are better. Conclusion Low concentrations of alcohol(≤15%) can effectively promote healing of ulcers by longer-term(48-72 hours); high concentration of alcohol(≥75%) disinfection also can effectively promote the healing of ulcers by short-term(24-48 hours). But the extension of the use of high concentration of alcohol is easy to stimulate ulcers and causes counter-productive.