摘要
煮的烟(CF ) 是许多有毒的部件的混合物,例如醛,杂环的胺,多不的芳香的烃,胖喷雾器和微粒事。CF 暴露被证明了与许多疾病被联系。肺癌症带头在疾病之中的地方正在被报导由 CF 暴露引起了。分子、生物化学的研究发现了 CF 暴露可以由基因损坏,反应的氧种类的形成,相关蛋白质功能的阻塞,和甚至房间死亡导致肺癌症。然而,关于 CF 暴露怎么导致肺癌症的机制的评论仍然正在缺乏。CF 暴露引起的肺癌症的机制的说明可以提供新卓见进 CF 暴露引起的肺癌症的预防,以及为 CF 的毒性学习打基础。在这次要的评论, CF 暴露怎么导致肺癌症的机制被总结并且讨论。
Cooking fumes (CFs) are mixtures of many toxic components, such as aldehydes, heterocyclic amines, polycyclic aromatic hydrocarbons, fat aerosols and particulate matters. CFs exposure has been proven to be associated with many diseases. Lung cancer takes the leading place among the diseases being reported caused by CFs exposure. Molecular and biochemical studies have found that CFs exposure may lead to lung cancer by gene damage, formation of reactive oxygen species, blockage of related proteins’ function, and even cell death. However, reviews about the mechanisms of how CFs exposure leads to lung cancer are still lacking. Elucidation of the mechanisms of lung cancer caused by CFs exposure may provide a new insight into the prevention of lung cancer caused by CFs exposure, as well as laying the foundation for the toxicity study of CFs. In this minor review, the mechanisms of how CFs exposure leads to lung cancer were summarized and discussed.
基金
Supported by the Development Project of Community Health Nursing Innovative Practice Model of China(CMB08883)