老年痴呆患者血清同型半胱氨酸、C反应蛋白、叶酸、维生素B_(12)检测研究

Detection of serum homocysteine,C reactive protein,folic acid and vitamin B_(12) in patients with Alzheimer's disease

目的检测老年痴呆患者(阿尔茨海默病、血管性痴呆)血清同型半胱氨酸、C反应蛋白、叶酸、维生素B12水平,探讨其对老年痴呆发生发展的临床意义。方法随机选择120例老年痴呆患者作为观察组研究对象,包含阿尔茨海默病患者64例,血管性痴呆患者56例,另选择同时期在本院接受检查的健康体检者50例作为对照组研究对象,对3组患者的血清同型半胱氨酸、C反应蛋白、叶酸、维生素B12水平变化进行比较和分析。结果 AD组同型半胱氨酸、C反应蛋白显著高于对照组,叶酸、维生素B_(12)水平显著低于对照组,各数据指标相比差异具有统计学意义(P<0.05);VD组同型半胱氨酸、C反应蛋白显著高于对照组,叶酸、维生素B12水平显著低于对照组,各数据指标相比差异具有统计学意义(P<0.05);AD组同型半胱氨酸、C反应蛋白显著高于VD组,数据比较差异具有统计学意义(P<0.05);AD组叶酸、维生素B12水平与VD组比较差异无统计学意义;AD组及VD组ADL生活质量评分均低于对照组(P<0.05),但AD组及VD组之间数据比较差异无统计学意义。结论血清同型半胱氨酸、C反应蛋白是老年痴呆发生的危险因素,患者痴呆严重程度与血清同型半胱氨酸浓度具有相关性,且血清同型半胱氨酸、C反应蛋白还可以作为鉴别阿尔茨海默病、血管性痴呆的依据。

Objective To detect the patients with senile dementia（Alzheimer＇s disease, vascular dementia） serum homocysteine, C reactive protein, folate, vitamin B12 levels, explore the clinical significance of the occurrence and development of Alzheimer＇s disease. Methods Randomly selected in our hospital in December 2016 December 2014 to 120 cases of senile dementia patients as the observation group. The object contains 64 cases of patients with Alzheimer＇s disease, 56 cases of patients with vascular dementia, and the other in the hospital examined 50 healthy cases as control group subjects. The serum cysteine on three groups of patients with type C reaction Protein, folic acid, vitamin B12 level changes were compared and analyzed. Results In group AD, homocysteine, C-reactive protein C was significantly higher than the control group, folic acid, vitamin B12 levels were significantly lower than the control group, with statistical significance of the data index difference（p〈0.05）; group VD, homocysteine, Creactive protein was significantly higher than that of C the control group, folic acid, vitamin B_（12） levels were significantly lower than the control group, with statistical significance of the data index difference（p〈0.05）; group AD, homocysteine, C-reactive protein C was significantly higher than that of VD group, with significant difference（p〈0.05）; group AD, folic acid, vitamin B12 and VD group the difference was not statistically significant; the ADL quality of life scores of AD group and VD group were lower than those of control group（p〈0.05）, but there was no significant difference between AD group and VD group. Conclusion Serum homocysteine, C-reactive protein C is a risk factor for the occurrence of dementia patients, associated with dementia severity and serum homocysteine concentrations, and serum homocysteine, C-reactive protein C also can be used to identify Alzheimer＇s disease and vascular dementia.