双亲性羧甲基壳聚糖钠盐席夫碱的合成及其作为多功能稳定剂的可行性研究

Synthesis of the Schiff′s Base of Carboxymethyl Chitosan Sodium and Its Feasibility as a Multi-functional Stabilizer

为设计并合成集助悬、润湿和防腐等功能于一体的混悬剂稳定剂,以提高混悬剂稳定性,保证用药安全有效,以壳聚糖为原料,分别与氯乙酸和柠檬醛反应合成双亲性的柠檬醛缩羧甲基壳聚糖钠盐席夫碱,并通过1H-NMR和元素分析对合成产物进行表征.黏度、亲水亲油平衡值和最低抑菌浓度的测试结果表明,通过引入羧甲基和席夫碱等基团,所合成的席夫碱衍生物具有助悬、润湿和抑菌3种功能;炉甘石混悬剂的稳定性实验表明,该合成产物能够提高混悬剂的稳定性,具有成为多功能稳定剂的潜力.

The Schiff′s base of carboxymethyl chitosan sodium was synthesized by the reaction of carboxymethyl chitosan sodium with citral.The structure of the Schiff′s base was characterized using 1H-NMR and elemental analysis,which confirmed that the amino groups in carboxymethyl chitosan reacted with citral to form the Schiff′s base.The viscosity,hydrophile-lipophile balance value and antibacterial properties of the products were also investigated.The results showed that the derivatives have potential as a high polymer suspension,wetting and antibacterial agent.The properties of the products as a stabilizer of suspensions were further investigated.Sedimentation rate and dispersion experiments showed that the product could improve the stability of the suspensions.