偏头痛风火候患者静息状态下脑功能连接的初步探讨

Rudimen analysis of connectivity changes in migraine's disease with feng-huo type in resting state

目的 :采用静息态f MRI探讨偏头痛风火候患者的自发神经元活动特征。方法 :纳入符合标准的30例偏头痛风火候患者和30例健康对照者,对其行静息态f MRI扫描。数据处理方法:(1)局部一致性(Re Ho)分析寻找差异脑区;(2)功能连接分析,选择Re Ho分析所得的差异脑区为种子点,进行种子点与全脑的功能连接分析。结果:(1)偏头痛组和对照组Re Ho值差异脑区为左侧小脑、左侧额叶直回、右侧上外额叶、右侧背外侧额上回、左侧边缘叶。(2)与对照组相比,各ROI与全脑功能连接情况为偏头痛风火候患者左侧小脑与左侧颞上回、左侧顶下小叶、右侧岛叶功能连接减弱(均P<0.05);左侧眶叶直回与右侧梭状回功能连接减弱(均P<0.05);右侧上外额叶与右侧小脑山坡、左侧额上回功能连接减弱,与左侧额眶皮质、右侧运动前区功能连接增强(均P<0.05);右侧背外侧额上回与左侧中央前回功能连接减弱,与右侧颞下回、右侧下脚后区功能连接增强(均P<0.05)。左侧边缘叶与全脑功能连接无差异。结论:偏头痛风火候患者头痛发作间期脑功能异常有助于理解风火候偏头痛的发病机制。

Object：Imageology study has shown that the brain structure and function in patients with migraine of feng-huo type have changed. This study used the characteristic of spontaneous neuronal activity in patients with migraine of feng-huo type to discuss resting state functional magnetic resonance imaging technology. The research also analyzed the change of migraine rest-ing state brain functional connectivity. It can give us a better understanding of the pathogenesis of migraine of feng-huo type. Methods：Incorparate 30 patients with migraine of feng-huo type,and also choose 30 healthy persons. They had the same age, gender,and education level. Compare the differences among them. Let them make resting state fMRI scan. Then use ReHo analysis and functional connectivity analysis to analyze the two kinds of methods of data processing：①ReHo analysis：through analyzing the differences of the two tested groups of ReHo in different brain regions to find out the different brain regions. Then use REST 1.8 single sample and two sample T test to find differences in brain areas. ②FC analysis：select differences in brain regions of local consistency analysis as the seed point,analyze the seed point and the whole brain function connectivity. Results：①The differences between migraine were in brain regions of ReHo for left cerebellum,left frontal straight back,right frontal lobe,right outside the dorsolateral frontal gyrus,the left edge of the leaf. ②Compared with healthy controls,the region of interest and whole brain functional connectivity showed that the functional connectivity of migraine patients with gout condition of heat left cerebellum and left superior temporal gyrus,left inferior parietal lobule,right insula decreased functional connectivity （P〈0.05）;the functional connectivity of the left orbital lobes straight back and right fusiform gyrus had decreased （P〈0.05）;the function of the right frontal lobe;outer connected with the right cerebellum,left superior frontal gyrus weaken. The functional connectivity of the frontal orbital region,right premotor area had increased （P〈0.05）. The functional connectivity of the right dorsolateral frontal gyrus and left precentral gyrus had decreased,connected with the foot back function enhancement of the right inferior temporal gyrus,the lower （P〈0.05）. The left edge of the leaf and whole brain functional connectivity were without difference. Conclusion：The patients with migraine of feng-huo type headache interval function appear abnormal brain regions. The pathogenesis of these findings contribute to the understanding of migraine of feng-huo type.