非复杂妊娠新生儿游离肉碱浓度与孕龄相关性研究

Correlation study of concentration of free carnitine and gestational age in neonates born in uncomplicated pregnancy

目的探讨非复杂妊娠新生儿干血片中游离肉碱浓度与孕龄间的关系。方法回顾性分析2014年12月-2015年8月本院进行代谢筛查的非复杂性妊娠的8979例新生儿其肉碱检测结果。采用高效液相色谱-串联质谱检测所有新生儿足跟血3干血片中肉碱浓度,分析肉碱浓度与孕龄间的关系。结果早产儿肉碱浓度高于非早产儿(P<0.05)。新生儿体内肉碱浓度与孕龄呈负相关,r=-0.034,95%置信区间(-0.056,-0.014),(P=0.001)。结论随孕龄增加,胎儿脂肪合成增加而至足月后逐渐达到饱和,肉碱的利用反映了这种趋势。

Objective To investigate the relationship between concentration of free carnitine and neonatal gestational age in uncomplicated pregnancy. Methods Concentration of free carnitine among 8979 cases who underwent uncomplicated pregnancies in our hospital and were carried out neonatal screening between August 2014 and December2015 were analyzed retrospectively. Dry blood spot were collected on the third day of neonatal life,detection was conducted by high performance liquid tandem mass spectrometry（HPLC-MS）. The relationship between concentration of carnitine and neonatal gestational age was analyzed by SPSS statistical analysis.Results The concentration of free carnitine in preterm birth infants was significantly higher than that in non-preterm birth infants（P0.05）. The concentration of carnitine was negatively correlated with neonatal gestational age,r=-0.034,95%CI（-0.056,-0.014）,（P=0.001）. Conclusion Metabolism of fetal fat synthesis increases gradually until full-term with the increase of gestational age,which can be reflected by the utilization of carnitine.