心脉隆注射液联合左西孟旦治疗老年急性心肌梗死后心力衰竭患者的疗效观察

Clinical effects of Xinmailong Injection combined with levosimendan in treatment of heart failure after acute myocardial infarction in elderly patients

目的:观察心脉隆注射液联合左西孟旦对急性心肌梗死后心力衰竭老年患者的疗效。方法:对我院心血管内科2015年2月~2016年12月收治的86例急性心肌梗死后心力衰竭老年患者进行分组,各43例。两组均给予左西孟旦等常规治疗药物,观察组另给予心脉隆注射液,分析该注射液对该疾病的效果。结果:(1)观察组总有效率为93.02%,明显高于对照组72.09%。经治疗,观察组LVEF、LVEDD和LVESD分别为(55.09±3.39%、53.49±2.04mm、41.19±1.52mm),均明显优于对照组(50.27±3.29%、56.39±2.11mm、44.01±1.76mm)。(3)经治疗,观察组NT-pro BNP、CK-MB和c Tn I水平分别为(658.3±29.4μg/L、19.48±2.86U/L、0.10±0.05μg/L),均明显低于对照组(713.9±34.8μg/L、24.15±2.97U/L、0.18±0.07μg/L)(均P<0.05)。(4)经治疗,观察组血清CRP、TNF-ɑ、IL-6水平分别为(3.17±1.09mg/L、364.1±23.1pg/ml、25.57±3.17ng/L),均明显低于对照组(5.06±1.15mg/L、485.7±25.4pg/ml、31.04±3.32ng/L)。(5)两组各不良反应率的差异均无统计学意义。结论:心脉隆注射液可减轻急性心肌梗死后心力衰竭老年患者的心肌损伤程度,提高其治疗效果。

Objective： To observe clinical effects of Xinmailong Injection combined with levosimendan in treatment of heart failure after acute myocardial infarction in elderly patients. Methods： 86 elderly patients with heart failure after acute myocardial infarction from February 2015-December 2016 in internal Medicine-Cardiovascular department were grouped two groups and each with 43 cases. Two groups were treated with levosimendan and observation group was treated another with Xinmailong injection to observe its effects. Results： Total efficiency of observation group was 93. 02%,significantly higher than that of control group72. 09%（ P〈0. 05）. After treatment,LVEF,LVEDD and LVESD of observation group were（ 55. 09 ± 3. 39%,53. 49 ± 2. 04 mm,41. 19 ± 1. 52mm）,better than that of control group（ 50. 27 ± 3. 29%,56. 39 ± 2.11 mm,44. 01 ± 1. 76mm）（ all P〈0. 05）.（3）After treatment,NT-pro BNP,CK-MB and c Tn I of observation group were（ 658. 3 ± 29. 4μg/L,19. 48 ± 2. 86U/L,0. 10 ± 0. 05μg/L）,lower than that of control group（ 713. 9 ± 34. 8μg/L,24. 15 ± 2. 97U/L,0. 18 ± 0. 07μg/L）（ all P〈0. 05）.（4）After treatment,serum CRP,TNF-ɑ,IL-6 level of observation group were（ 3. 17 ± 1. 09mg/L,364. 1 ± 23. 1pg/ml,25. 57 ± 3. 17ng/L）,lower than that of control group（ 5. 06 ± 1. 15mg/L,485. 7 ± 25. 4pg/ml,31. 04 ± 3. 32ng/L）（ all P〈0. 05）.（5）During treatment,there was no significant difference in the adverse reaction rate between the two groups（ P〈0. 05）. Conclusion： Xinmailong injection can reduce the degree of myocardial injury and improve herapeutic effect.