运脾逐湿汤治疗湿热困脾型高血压代谢综合征

Effect of Yunpi Zhushi Decotion Treating Spleen Damp-heat Type Hypertension Metabolic Syndrome

目的:探讨运脾逐湿汤治疗湿热困脾型代谢综合征(MS)高血压患者的疗效及对血清中脂联素(ADP),高敏C反应蛋白(hs-CRP),同型半胱氨酸(HCY),内皮素(ET)和血管性血友病因子(v WF)水平的影响。方法:本研究将纳入的MS高血压患者118例随机分为对照组和治疗组各59例。对照组口服替米沙坦片,40 mg/次,1次/d。治疗组在对照组治疗的基础上给予运脾逐湿汤内服,1剂/d,分早晚2次服用。两组连续治疗3个月。比较两组血压变异性、形体学指标、血脂水平和血糖相关指标。检测两组患者血清中ADP,hs-CRP,HCY,ET和v WF水平。结果:治疗后,两组患者治疗后24 h舒张压标准差(24 h DSD),夜间舒张压标准差(n DSD),白天收缩压标准差(d SSD)及白天舒张压标准差(d DSD)均比治疗前明显下降(P<0.01),但两组间比较差异无统计学意义。治疗后治疗组患者的形态学指标、血脂水平和血糖水平均明显下降,且均明显低于对照组(P<0.01)。治疗组治疗后血清中ADP明显高于对照组,hs-CRP,HCY,ET和v WF水平明显低于对照组,比较差异有统计学意义(P<0.01)。结论:在西医治疗的基础上,加服运脾逐湿汤治疗湿热困脾型MS高血压疗效明显,且可提高患者血清中ADP水平和降低hs-CRP,HCY,ET和v WF水平。

Objective： To investigate the efficacy of Yunpi Zhushi decoction in treating hypertension patients with spleen damp-heat type metabolic syndrome （MS）, and observe its effect on serum levels of adiponectin （ADP）, high-sensitive-C-reactive protein （hs-CRP）, homoeysteine （Hey）, endothelin （ET）, and vascular von willebrand factor （vWF）. Method： One hundred and eighteen patients with MS hypertension were randomly divided into control group and treatment group （59 cases in each group）. The patients in control group orally took Telmisartan tablets （40 mg/time and 1 time/day）. Based on the treatment in control group, the patients in treatment group were given with Yunpi Zhushi decoction, 1 dose/day, twice daily in night and morning. All patients were continuously treated for 3 months. Then indexes of blood pressure variability, physique study, blood fat, and blood glucose were compared between two groups. And the serum levels of ADP, hs-CRP, HCY, ET, and vWF were detected in both groups. Result： After treatment, 24 h diastolic pressure standard deviation （24 hDSD） , diastolic pressure standard deviation at night （nDSD）, systolic pressure standard deviation at daytime （dSSD） , and diastolic pressure standard deviation at daytime （dDSD） were obviously decreased in both groups （P 〈0.01 ） , but there was no statistically significant difference between two groups. After treatment, indexes of physique study, blood fat, and blood glucose were obviously decreased in treatment group, and lower than those of control group （P 〈0.01）. Serum level of ADP in treatment group was remarkably higher, while hs-CRP, HCY, ET, and vWF were lower than those in control group with statistically significant differences （P 〈 0.01 ）. Conclusion： Based on western medicine, Yunpi Zhushi decoction has obvious efficacy in treating hypertension patients with spleen damp-heat type metabolic syndrome, and can up-regulate serum level of ADP and down- regulate serum levels of hs-CRP, Hcy, ET, and vWF.