工作相关肌肉骨骼损伤生物标志物的研究进展

Research progress on biomarkers of work-related musculoskeletal disorders

工作相关肌肉骨骼损伤(WMSDs)是常见的职业性疾患,其患病率高、危害大、造成的经济损失严重,是全球职业健康领域亟待解决的重要问题。WMSDs是多因素影响的慢性累积性疾病,且发病机制尚不明确,在临床和职业环境中进行鉴定比较困难,目前主要依靠现场问卷调查和简单的体征检查,然而这些方法本身存在一定局限性,因而急需建立基于生物标志物的客观检测与评价指标。WMSDs生物标志物的研究对于肌肉骨骼损伤的早期诊断和健康监测都具有非常积极的作用。本文将WMSDs生物标志物简单分为3类:(1)组织代谢生物标志物;(2)炎性生物标志物;(3)疼痛相关生物标志物,并详述了国内外相关研究的新进展。

Work-related musculoskeletal disorders（WMSDs） are a common subset of occupational diseases with a high prevalence and a serious impact on health, which result in heavy economic loss, thus are an urgent problem to be solved in occupational health research field worldwide. Since WMSDs are chronic cumulative diseases affected by a variety of risk factors and their pathogenesis is not yet clear, their identification is difficult in clinical and occupational environment and currently mainly relies on questionnaire survey and physical examination. However, there are inherent limitations of these methods. Thus, it is imperative to develop objective detection and evaluation indicators based on biomarkers. The study of WMSDs biomarkers will have a positive effect on the early diagnosis and health monitoring of WMSDs. In this paper, WMSDs biomarkers were simply divided into three categories： tissue metabolite biomarkers, inflammatory biomarkers, and pain-related biomarkers, and the recent progress of related research at home and abroad were reviewed.