全氟辛烷磺酸神经毒性研究进展

Current neurotoxicity research on perfluorooctane sulfonate

全氟辛烷磺酸(PFOS)作为一种持久性极强、极难分解的有机污染物,近年来越来越受到各领域研究者的关注。本文从PFOS的转运和代谢、神经毒性表现以及其可能的毒作用机制(包括影响神经细胞的生长分化及脑发育,影响神经突触的形成及其可塑性,影响神经递质的产生,影响离子通道的稳定,引发神经炎症,引起神经细胞氧化应激)等方面,对近年来PFOS的神经毒性研究作一综述。

Perfluorooctane sulfonate（PFOS） as an extremely persistent and refractory organic pollutant has attracted increasing attention from researchers in various fields in recent years. This paper reviewed PFOS transport and metabolism, neurotoxicity, and possible mechanisms, including inhibiting neuron growth differentiation and brain development, affecting synaptogenesis and plasticity, suppressing neurotransmitter production, disturbing ion channels, and inducing neuroinflammation oxidative stress in neuron cells.