抗生素联合脂溶性维生素治疗小儿肺炎的全身情况及炎症反应程度评估

Evaluation of the general conditions and inflammatory response of antibiotics combined with fat-soluble vitamin therapy for pediatric pneumonia

目的:探讨抗生素联合脂溶性维生素治疗小儿肺炎的全身情况及炎症反应程度评估。方法:收集2014年1月~2017年1月间在本院接受治疗的肺炎患儿350例,按照随机数表法分为对照组、观察组,各175例。对照组患儿接受阿奇霉素治疗,观察组患儿接受阿奇霉素联合脂溶性维生素治疗,对比两组患儿治疗前后全身状况及炎症反应的差异。结果:治疗前,两组患者血常规指标水平,血清氧化应激指标及炎症因子含量的差异无统计学意义(P>0.05)。治疗后,两组患者的白细胞计数、中性粒细胞比例以及血清中C反应蛋白(CRP)、降钙素原(PCT)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)的含量均低于治疗前,淋巴细胞比例以及血清中IgA、IgG、IgM的含量均高于治疗前(P<0.05),且观察组患儿治疗后的白细胞计数、中性粒细胞比例以及血清中CRP、PCT、IL-6、TNF-α的含量低于对照组患儿,淋巴细胞比例以及血清中IgA、IgG、IgM的含量高于对照组患儿(P<0.05)。结论:抗生素联合脂溶性维生素治疗小儿肺炎,可有效优化患儿的全身状况,降低炎症反应。

Objective： To evaluate the general conditions and inflammatory response of antibiotics combined with fat soluble vitamin therapy for pediatric pneumonia. Methods： A total of 350 children with pneumonia who were treated in our hos- pital between January 20114 and January 2017 were collected and divided into control group and observation group according to the random number table, 175 cases in each group. Control group received azithromycin therapy, and observation group re- ceived azithromycin combined with fat-soluble vitamin therapy. The differences in the systemic and inflammatory responses be fore and after treatment were compared between the two groups of patients. Results： Before treatment, differences in blood routine index levels as well as serum contents of oxidative stress indexes and inflammatory factors were not statistically signifi- cant between two groups of patients （P〉0.05）. After treatment, white blood cell count, neutrophil ratio as well as serum CRP, PCT, IL-6 and TNF-α contents of both groups were lower than those before treatment while lymphocyte ratio as well as serum IgA, IgG and IgM contents was significantly higher than those before treatment （P〈0.05）, and white blood cell count, neutrophil ratio as well as serum CRP, PCT, IL-6 and TNF-a contents of observation group after treatment were lower than those of control group while lymphocyte ratio as well as serum IgA, IgG and IgM contents was higher than those of control group （P〈0.05）. Conclusion： Antibiotics combined with fat-soluble vitamin therapy for pediatric pneumonia can effectively op- timize the patients~ general conditions and reduce the inflammatory response.