度洛西汀联合神经阻滞治疗颈源性头痛的疗效

CLINICAL EFFICACY OF DULOXETINE COMBINDED WITH NERVE BLOCK ON CERVICOGENIC HEADACHE

目的:探讨度洛西汀联合神经阻滞治疗颈源性头痛(cervicogenic headache,CEH)的临床疗效。方法:选取2016年1月至2017年2月来我院疼痛科诊治的CEH病人40例,随机分为对照组与治疗组,每组各20例。对照组给予外周神经阻滞治疗,治疗组采用外周神经阻滞联合口服度洛西汀。治疗前后两组均采用视觉模拟评分法(visual analogue scale,VAS)和睡眠质量(quality of sleep,QS)评分进行疼痛程度评分,评估临床治疗效果,同时观察不良反应。结果:对照组和治疗组治疗后VAS评分和QS评分均较治疗前降低(P<0.05),治疗组VAS和QS评分明显低于对照组(P<0.05)。两组均无严重不良反应。结论:度洛西汀联合外周神经阻滞可以有效改善CEH,联合治疗疗效优于单一治疗,且未见明显不良反应。

Objective：To evaluate the clinical efficacy of duloxetine combined with nerve block on cervicogenic headache （CEH）.Methods：Total 40 CEH patients were randomly divided into control group given nerve block and treatment group received duloxetine combined with nerve block （n = 20, respectively）. Visual analogue scales （VAS） and quality of sleep （QS） were evaluated, and the adverse reactions were also observed.Results：The VAS and QS scores of treatment group were significantly decreased compared with before and control group （P〈 0.05）. No significant side effects were found in both groups.Conclusion： Combination treatment showed better effects than nerve block lonely and without obvious adverse side effects.