定眩止晕汤联合长春司汀治疗椎-基底动脉供血不足眩晕的疗效及其对氧化应激的影响

Impact of Dingxuan Zhiyun decoction Combined with Vinpocetine on Oxidative Stress in Vertigo Patients Caused by Vertebro-basilar Arterial Insufficiency

目的:观察定眩止晕汤联合长春司汀治疗椎-基底动脉供血不足眩晕的临床疗效及其对氧化应激的影响。方法:选择符合纳入标准的椎-基底动脉供血不足眩晕患者92例,按照抽签法,随机分为观察组和对照组,每组46例。对照组予以长春司汀治疗,观察组在对照组基础上予以定眩止晕汤。观察两组患者临床疗效,两组治疗前后血液黏度,椎动脉和基底动脉的平均血流速度和血管搏动指数,超氧化物歧化酶(SOD),丙二醛(MDA)和一氧化氮(NO)水平的变化。结果:观察组的总有效为95.65%明显高于对照组的78.26%,两组比较差异有统计学意义(χ2=4.696,P<0.05)。两组患者治疗前的全血高切黏度,全血低切黏度,血浆比黏度,椎动脉、基底动脉的平均血流速度和血管搏动指数,SOD,MDA和NO比较差异无统计学意义(P>0.05),治疗后两组患者全血高切黏度,全血低切黏度,血浆比黏度,椎动脉、基底动脉的血管搏动指数和MDA均较治疗前明显降低(P<0.01),椎动脉、基底动脉血流速度,SOD和NO较治疗前明显增高(P<0.01),观察组升高或者降低水平更为明显(P<0.01)。结论:定眩止晕汤联合长春司汀治疗椎-基底动脉供血不足眩晕疗效显著,具有改善机体血液黏度和缓解机体氧化应激的作用。

Objective：To observe the efficacy of Dingxuan Zhiyun decoction combined with Vinpocetine in vertigo patients caused by vertebral-basal arterial insufficiency,and its impact on oxidative stress.Methods：92 vertigo patients caused by vertebral-basal arterial insufficiency were randomly divided into the observation group and the control group by drawing lots,with 46 cases in each group.The control group was given Vinpocetine,and the observation group was treated by Dingxuan Zhiyun decoction combined with Vinpocetine.The clinical efficacy,the levels of blood viscosity,average blood flow velocity and vascular pulsatility index of vertebro-basilar artery,the levels of superoxide dismutase （SOD）,malonaldehyde （MDA） and nitric oxide （NO） were observed before and after treatment in both groups.Results：The total effective rate was significantly higher in the observation group（95.65%） than that in the control group（78.26%）,the difference was statistically significant （χ2=4.696,P〈0.05）.The levels of high-shear blood viscosity,low-shear blood viscosity,plasma viscosity,mean blood flow velocity and pulsatility index of vertebro-basilar artery,SOD,MDA and NO were not statistically different between two groups before treatment （P〉0.05）,after treatment,the levels of high-shear and low-shear of blood viscosity,plasma viscosity,pulsatility index of vertebral artery-basilar artery and MDA significantly decreased than those before treatment （P〈0.01）,the levels of blood flow velocity of vertebro-basilar artery,SOD and NO were significantly higher compared to those before treatment （P〈0.01）,the increasing or decreasing changes in the observation group were more significantly than those in the control group （P〈0.01）.Conclusion：The efficacy of Dingxuan Zhiyun decoction combined with Vinpocetine is significant,the mechanism may be related with improving the bodys blood viscosity and relieving oxidative stress.