凉血散瘀汤联合尼莫地平治疗脑出血后缺血性脑损伤的临床研究

Clinical Study on Liangxue Sanyu decoction Combined with Nimodipine for Ischemic Brain Injury after Cerebral Hemorrhage

目的:观察分析凉血散瘀汤联合尼莫地平治疗脑出血后缺血性脑损伤的临床疗效。方法:将符合纳入标准的72例脑出血后缺血性脑损伤患者按照随机对照法分为观察组与对照组,每组36例。对照组患者采用尼莫地平治疗,观察组患者在对照组治疗基础上加服凉血散瘀汤,两组患者均治疗14 d。观察凉血散瘀汤联合尼莫地平对脑出血后缺血性脑损伤患者脑水肿体积、NIHSS评分、BI评分的影响,探讨其临床疗效。结果:两组患者治疗后脑水肿体积均明显减少,NIHSS评分明显降低,BI评分明显升高,与治疗前比较,差异极显著(P<0.01);且观察组患者脑水肿体积减少,NIHSS评分、BI评分改善情况均明显优于对照组,差异显著(P<0.05)。结论:凉血散瘀汤联合尼莫地平可有效减少脑出血后缺血性脑损伤患者脑水肿体积,改善NIHSS评分、BI评分,可见两者联合应用治疗脑出血后缺血性脑损伤具有较好的临床疗效。

Objective：To evaluate the clinical curative effect of Liangxue Sanyu decoction combined with Nimodipine for ischemic brain injury after cerebral hemorrhage.Methods：72 patients with ischemic brain injury after cerebral hemorrhage were randomly divided into the observation group and the control group,with 36 cases in each group.The control group was treated with Nimodipine,on which basis,the observation group was also given Liangxue Sanyu decoction,and the course of the medication was 14 days.The hydrocephalus degree,NIHSS score,and BI score of the two groups were compared to discuss the clinical curative effect.Results：After medication,the hydrocephalus degree and NIHSS score reduced significantly,with obvious increase of BI score in both groups,of which there were significant differences compared to those before treatment（P〈0.01）;and the changes of the observation group were greater than those of the control group（P〈0.05）.Conclusion：Liangxue Sanyu decoction combined with Nimodipine can significantly reduce hydrocephalus degree and decrease NIHSS score,but increase BI score,which shows that this kind of medication has a good effect on ischemic brain injury after cerebral hemorrhage.