C-反应蛋白的动态变化对难治性类风湿关节炎的预测价值分析

Analysis of Predictive Value of Dynamic Changes of C-reactive Protein in Refractory Rheumatoid Arthritis

目的浅析血清CRP(C-反应蛋白)的变化在RRA(难治性类风湿关节炎)临床预测中的价值。方法回顾性2016年1月—2017年1月在浙江萧山医院确诊的100例类风湿关节炎患者作为研究病例,依据甲氨蝶呤片与柳氮磺胺吡啶肠溶片两种药物治疗6个月后的临床疗效,将100例患者随机分为实验组和对照组。其中,药物治疗无效的25例患者纳入实验组,其余75例纳入对照组。检测药物治疗前、治疗后12、16、20、24周的血清CRP含量,并用DAS28值评价患者的疾病活动度。结果药物只治疗24周的随访结果显示,RRA的发生率是25%。药物治疗24周,实验组患者的CRP含量是(14.38±3.88)mg/L,呈现出动态变化,且各时间段的含量均明显高于对照组(P<0.05)。结论实验组RRA患者血清CRP水平随时间推移所呈现出的动态变化,可以在某种程度上作为预测RRA的重要依据。

Objective To analyze the predictive value of dynamic changes of c-reactive protein in refractory rheumatoid arthritis. Meth- ods 100 cases of patients with rheumatoid arthritis diagnosed in our hospital from January 2016 to January 2017 were selected and randomly divided into two groups according to the clinical curative effect after 6-month treatment of methotrexate and sulfasalazine sasp tablets, the experimental group were 25 cases whose drug treatment was ineffective, and the other 75 cases were included into the control group, and the serum CRP contents in 12 weeks, 16 weeks, 20 weeks and 24 weeks after treatment and before treatment were tested and the disease activity degree of patients was evaluated by the DAS28 value. Results The 25-week follow-up results showed that the incidence rate of RRA was 25%, and the CRP content in the experimental group after 24-week drug treatment was （14.38±3.88）rag/L, showing a dynamic change, and the contents in various time phases were obviously higher than those in the con- trol group （P〈0.05）. Conclusion As the time goes by, the serum CRP level has a dynamic change of RRA disease patients in the ex- perimental group, which can be used as an important basis of predicting the RRA to a certain degree.