辅助生殖技术对子代印记基因影响的研究进展

Impacts of assisted reproductive technology on genomic imprinting in filial generation

辅助生殖技术(assisted reproductive technology,ART)是采用医学技术手段使不孕不育夫妇获得妊娠一系列技术的统称,与自然妊娠相比,在体内、体外环境等有所不同,配子及早期胚胎遭受医源性应激,致子代健康风险增加。目前普遍认为ART与配子及早期胚胎印记基因印迹改变相关,进而影响子代出生后远期健康。本文就ART对印记基因的影响进行综述,分别从配子、植入前胚胎、胎盘等方面进行论述,总结了ART与印记基因印迹异常的关系。

Using a range of medical techniques to make infertile couples get pregnancy is collectively called assisted reproductive technology （ART）, which is dissimilar from natural pregnancy in many respects such as in vitro and in vivo environments. Gametes and early embryos suffer from iatrogenic stress, and will cause an increase m children health risks. Currently, it is widely believed that ART is related to the abnormal expression of imprinted genes, and then affects the health of offspring. This paper reviews the impacts of ART on genomic imprinting from three aspects such as the gametes, preimplantation embryo and the placenta, which summarizes the relationship between assisted reproduction technology and the abnormal imprinted genes.