新辅助化疗在晚期卵巢癌治疗中的应用效果及对卵巢血流参数的影响

Application of Neoadjuvant Chemotherapy in the Treatment of Advanced Ovarian Cancer and Influence on the Ovarian Blood Flow Parameters

目的探讨新辅助化疗在晚期卵巢癌治疗中的应用效果及对卵巢血流参数的影响。方法将58例晚期卵巢癌患者随机分为对照组29例和观察组29例。对照组进行常规卵巢癌治疗,观察组则在常规治疗前进行新辅助化疗,然后将2组患者的治疗总有效率及治疗前后的血清肿瘤标志物、血流参数及血管参数进行比较。结果观察组的治疗总有效率高于对照组,治疗后不同时间的血清肿瘤标志物水平均低于对照组,血流参数及血管参数均好于对照组,P均<0.05。结论新辅助化疗在晚期卵巢癌治疗中的应用效果较好,对卵巢血流参数的影响也较为积极,应用价值高。

Objective To observe the application of neoadjuvant chemotherapy in the treatment of advanced ovarian cancer and influence on the ovarian blood flow parameters. Methods 58 patients with advanced ovarian cancer were randomly divided into the control group 29 cases and the observation group 29 cases, the control group were treated with conventional treatment of ovarian cancer, the observation group were treated with neoadjuvant chemotherapy on the conventional treatment, then the total effective rates, serum tumor markers ,blood flow parameters and blood vessel parameters before and after the treatment of the 2 groups were compared. Results The total effective rate of the observation group was higher than that of the control group, the serum tumor markers at different time after the treatment were all lower than those of the control group, the blood flow parameters and blood vessel parameters were all better than those of the control group, all P 〈 0.05, the differences of the 2 groups were all significant. Conclusion The application effect of neoad）nvant chemotherapy in the treatment of advanced ovarian cancer is good, and the influence on ovarian blood flow parameters is active,it has high application value.