基于转基因秀丽隐杆线虫模型的抗阿尔茨海默病中药成分筛选思路

Transgenic Caenorhabditis elegans Model Put Forward the Methods of Screening Chinese Medicine for Anti-Alzheimer's Disease

转基因秀丽隐杆线虫(Caenorhabditis elegans)是近20年发展起来的优良衰老模型,被应用于包括阿尔茨海默病在内的神经退行性病变的药物筛选与基因组学研究。秀丽隐杆线虫模型具有操作简单、筛选周期短、能提供多个靶点等特点,分析了利用其进行抗阿尔茨海默病中药成分筛选的可行性与优势,以期为药学工作者提供新思路。

Transgenic Caenorhabditis elegans has been developed as an excellent aging model for nearly two decades, and widely applied in neurodegenerative disease drug screening and genomics research, especially in the study of Alzheimer＇s disease. The tansgenic Caenorhabditis elegans takes advatage of feasibility, short life circles, and being simutanuously applicable to multiple targets. The present article evaluated the advantages of screening Chinese medicines for anti-Alzheimer＇s disease drug using transgenic Caenorhabditis elegans model, and provided new ideas for pharmacy workers.