广州地区儿童维生素D营养状况及其与超重肥胖关系的研究

Association between the status of vitamin D with overweight and obesity of children in Guangzhou

目的了解广州地区儿童维生素D(Vit D)营养状况,分析儿童超重肥胖与Vit D营养状况的关系,为儿童Vit D的合理补充、预防Vit D缺乏性疾病提供科学依据。方法采用横断面研究,收集广东省妇幼保健院健康体检儿童的年龄、性别,测量身高、体重,计算体质指数(BMI),采集空腹静脉血,用化学发光法检测血清中25-羟维生素D[25-(OH)D]水平。结果共收集7 578名儿童,血清25-(OH)D平均水平为(98.57±39.96)nmol/L,其中男童为(98.58±39.64)nmol/L,女童为(98.56±40.38)nmol/L,差异无统计学意义(P>0.05);658名儿童Vit D缺乏(8.68%)、1 602名儿童Vit D不足(21.14%),不同性别儿童Vit D缺乏率及不足率差异无统计学意义(P>0.05)。不同年龄儿童血清25-(OH)D水平差异有统计学意义(P<0.05),血清25-(OH)D水平随年龄增加逐渐下降;不同年龄儿童Vit D营养状况差异有统计学意义(P<0.05),Vit D缺乏率及不足率随年龄增加而升高(χ2趋势=275.266,P<0.05)。超重、肥胖儿童血清25-(OH)D水平低于正常儿童,差异有统计学意义(P<0.05);超重、肥胖儿童Vit D缺乏率及不足率均高于正常儿童,差异有统计学意义(P<0.05)。血清25-(OH)D水平与BMI呈负相关(P<0.001)。结论广州地区学龄儿童和超重肥胖儿童Vit D营养状况均较差,应重视儿童尤其是学龄儿童、超重、肥胖儿童Vit D的合理补充。

Objective To explore the association of the status of vitamin D with overweight and obese children in Guangzhou,and to provide measures for the prevention of vitamin D deficiency. Methods A cross sectional study was used to investigate physical examination and laboratory test among the children in Guangzhou.Chemiluminescence was used to detect the level of serum 25-hydroxy vitamin D [25-（OH）D]. Results The average level of serum 25-（OH）D was（98.57±39.96）nmol/L with（98.58±39.64）nmol/L in boys and（98.56±40.58）nmol/L in girls and there was no statistical difference between different genders（P0.05）.The prevalence rates of vitamin D deficiency and insufficiency were8.68% and 21.14% respectively,and there was no statistical difference between different genders（P0.05）.With the increasing of age,the level of serum 25-（OH）D decreased（P0.05）,and the prevalence rates of vitamin D deficiency and insufficiency increased（P0.05）.The level of serum 25-（OH）D was lower in overweight and obese children than those in normal children（P0.05）.The prevalence rates of vitamin D deficiency and insufficiency in overweight and obese children were higher than those in normal children（P0.05）.There was negative correlation between 25-（OH）D and BMI（P0.001）. Conclusions The status of vitamin D is poor in school children as well as overweight and obese children in Guangzhou.Comprehensive measures should be taken to improve the status in vitamin D of children especially of school children,overweight and obese children in Guangzhou.