摘要
Wireframe, polyhedral, supramolecular complexes made of DNA have uniform sizes, defined three-dimensional shapes, porous facets, hollow interiors, good biocompatibilities, and chemical functionalizability. They confer great potentials in bottom-up nanoengineering towards various applications. In this review, we summarize recent ad- vances in the rational design and programmed assembly of DNA wireframe polyhedra. Their assembly is based on three distinctively different strategies： individual strands-based assembly, tile-based assembly, and scaffolded DNA origami. Applications of these polyhedral structures in templated nanomaterial assembly and in-vivo cargo delivery are discussed. In the future, expanding the structural complexity and exploring their applications, especially in na- nomaterials science and biomedicines, should be a primary focus of this rapidly developing and evolving activity of structural DNA nanotechnology.
Wireframe, polyhedral, supramolecular complexes made of DNA have uniform sizes, defined three-dimensional shapes, porous facets, hollow interiors, good biocompatibilities, and chemical functionalizability. They confer great potentials in bottom-up nanoengineering towards various applications. In this review, we summarize recent ad- vances in the rational design and programmed assembly of DNA wireframe polyhedra. Their assembly is based on three distinctively different strategies： individual strands-based assembly, tile-based assembly, and scaffolded DNA origami. Applications of these polyhedral structures in templated nanomaterial assembly and in-vivo cargo delivery are discussed. In the future, expanding the structural complexity and exploring their applications, especially in na- nomaterials science and biomedicines, should be a primary focus of this rapidly developing and evolving activity of structural DNA nanotechnology.
基金
This work was supported by the National Natural Science Foundation of China （Nos. 21273214, 21521001 and 21605033）, the National Science Fund for Distinguished Young Scholars （No. 21425521）, the National Key Research and Development Program of China （No. 2016YFA0201300）, Hefei Center for Physi- cal Science and Technology （No. 2014FXCX010）, the Collaborative Innovation Center of Suzhou Nano Science and Technology, the Fundamental Research Funds for the Central Universities （No. JZ2016HGPA0734）, and start-up funding from Hefei University of Technology.
