中药康莱特联合化疗对乳腺癌患者T细胞亚群及肿瘤标志物的影响研究

Study on the effect of Kanglaite injection combined with chemotherapy on T cell subsets and tumor markers in patients with breast cancer

目的探讨康莱特联合化疗对乳腺癌患者T细胞亚群及肿瘤标志物的影响。方法选取2015年1月-2016年6月本院收治的乳腺癌患者110例作为研究对象,分为联合组55例和对照组55例,联合组与对照组均接受CAF化疗方案,联合组在化疗的基础上加用康莱特注射液,检测并比较2组治疗前后CD3^+、CD4^+、CD8^+、CD4^+/CD8^+水平以及癌胚抗原(CEA)、糖类抗原125(CA125)、糖类抗原15-3(CA15-3)水平。结果治疗后联合组的CD3^+、CD4^+、CD4^+/CD8^+水平显著高于治疗前,且显著高于同期对照组;治疗后对照组的CD4^+水平显著低于治疗前,上述差异有统计学意义(P<0.05)。治疗后联合组的CEA、CA125、CA15-3水平低于对照组,2组的CEA、CA125、CA15-3水平均比治疗前降低,差异有统计学意义(P<0.05)。结论康莱特联合化疗可有效治疗乳腺癌,降低肿瘤标志物水平,显著改善乳腺癌患者T细胞亚群水平,提高患者免疫功能。

Objective To investigate the effect of Kanglaite combined with chemotherapy on T cell subsets and tumor markers in patients with breast cancer. Methods 110 cases of breast cancer patients in our hospital from January 2015 to June 2016 were randomly divided into combined group（ n = 55） and control group（ n = 55）,which were both treated with CAF chemotherapy,the combined group used Kanglaite injection at the same time. The levels of CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋and the levels of carcinoembryonic antigen（ CEA）,carbohydrate antigen 125（ CA125） and carbohydrate antigen 15-3（ CA15-3） were detected and compared between the two groups before and after treatment. Results The levels of CD3^＋,CD4^＋,CD8^＋,CD4^＋/CD8^＋in the combined group after treatment were higher than that before the treatment and that in the control group; and after treatment,the CD4^＋level in the control group was significantly lower than that before treatment,with the differences statistically significant（ P〈0. 05）. After treatment,the levels of CEA,CA125 and CA15-3 in the combined group were lower than those in the control group,the levels of CEA,CA125 and CA15-3 in the two groups were lower than those before treatment,and the differences were statistically significant（ P〈0. 05）. Conclusion Kanglaite injection combined with chemotherapy can be effective in the treatment of breast cancer,which can reduce the levels of tumor markers,and significantly improve the levels of T cell subsets,so as to improve the immune function of patients.