摘要
银杏内酯是银杏叶的重要活性成分,主要包括银杏内酯A、B、C和白果内酯等,具有调节血压和拮抗血小板活化因子等多种药理作用。本文总结分析了近年来有关银杏内酯药代动力学的研究,主要包括银杏内酯在体内吸收、分布、代谢和排泄的过程。为了提高其生物利用度和药效,现研究者采用多种新剂型、新技术制备银杏内酯制剂。文中归纳总结了银杏内酯制剂的制备和特点,旨在为提高银杏内酯生物利用度的研究提供参考。
Ginkgo Terpene Lactones (GTL) is an important active ingredient of ginkgo biloba, mainly includingginkgo lactone A, B, C and bilobalide possess different biological activities such as peripheral vasoregulation, platelet-activating factor (PAF) receptor antagonism. GTL pharmacokinetic study in recent years, mainly including process ofabsorption, distribution, metabolism and excretion, was analyzed and summarized. In order to improve its bioavailabilityand efficacy, a variety of new formulations and technology was used to prepare GTL. The preparation and characteristics ofGTL were summarized, to provide the reference of improving the GTL bioavailability.
出处
《广州化工》
CAS
2017年第18期3-5,共3页
GuangZhou Chemical Industry
关键词
银杏内酯
药代动力学
剂型
Ginkgo Terpene Lactones (GTL)
pharmacokinetic study
dosage form