高压氧不同时间窗治疗对颅脑损伤患者认知功能的影响

Influence of hyperbaric oxygen window with different time for the cognitive function in treatment of patients with craniocerebral injury

目的研究高压氧治疗颅脑损伤患者在不同时间的临床治疗效果。方法选取2013-01—2016-01我院确诊为颅脑损伤的患者300例,随机分为3组进行研究,Ⅰ组83例为1周内行高压氧治疗的患者;Ⅱ组95例为入院1~4周行高压氧治疗的患者;Ⅲ组122例为4周以上行高压氧治疗的患者。记录3组治疗前与治疗后NCSE评分,采用FIM对3组患者行独立功能评价,比较治疗前后的总有效率。结果经我院高压氧治疗后3组患者认知功能及独立功能均明显有效于治疗前(P<0.05),Ⅰ组的认知功能优于Ⅱ组和Ⅲ组(P<0.05),但Ⅱ组和Ⅲ组无差异性(P>0.05);FIM评价治疗后3组患者恢复效果明显高于治疗前(P<0.05);Ⅱ组、Ⅲ组患者FIM数据明显低于Ⅰ组,差异具有统计学意义(P<0.05),Ⅱ组、Ⅲ组间无显著差异(P>0.05),Ⅰ组治疗总有效率显示高于其他2组,差异具有统计学意义(P<0.05)。结论早期接受高压氧治疗可明显缓解或治愈颅脑损伤,最大程度提升认知功能,促使患者早日恢复自主生活能力,值得推广应用。

Objective To study the clinical effects of hyperbaric oxygen therapy for patients with craniocerebral injury at different times.Methods 300 cases of patients who diagnosed craniocerebral injury in our hospital from January 2013 to January2016were selected,and 300 patients were divided into three groups for research.The group I of patients with craniocerebral injuries of 83 patients who were received hyperbaric oxygen therapy in our hospital within 1weeks,and group II of 95 patients with craniocerebral injuries admitted for 1-4weeks were treated with hyperbaric oxygen,while the group III of patients with craniocerebral injury were treated with hyperbaric oxygen for more than 4weeks in our hospital.Then,the score of NCSE before and after the treatment were recorded between the three groups,and the independent function of the three groups were evaluated by the FIM methods.The total effective rate of three groups before and after treatment were counted by the data,and the date outcomes were compared.Results The results showed that the cognitive function and independent function of three groups of patients after underwent hyperbaric oxygen treatment were significantly effective than that before the treatment（P0.05）,and the cognitive function in the group I were stronger than that in group Ⅱ and group Ⅲ（P0.05）,and there was no difference in the group II and group III（P0.05）;FIM evaluation of comparsion of data of three groups after treatment showed that the effect of recovery was higher than before treatment（P0.05）.The data FIM score showed that the data of patients with craniocerebral injury in the groupⅡand the group Ⅲ were significantly lower than that in group I,and the difference was statistically significant（P0.05）;The data showed that there was no significant difference between the two groups in group Ⅱ and group Ⅲ of craniocerebral injury（P0.05）.The total effective rate of patients with craniocerebral injury in the groupⅠ was higher than that of the other two groups,and the difference was statistically significant（P0.05）.Conclusion The early hyperbaric oxygen therapy can obviously alleviate or cure brain injury,and can improve the cognitive function and promote the patient＇s ability to live independently.Therefore,it is worth promoting and applying.