甲硝哒唑与庆大霉素用于腹部手术后预防感染的合理性研究

The Rationality of Combined Administration of Metronidazole and Gentamycin for Perioperative Prophylaxis of Infection after Abdominal Surgery

本文分别建立了监测甲硝哒唑血浓度的Hplc法和监测庆大霉素血浓度的FPIA法,考察我院甲硝哒唑与庆大霉素联合用于腹部术后预防感染的合理性。针对存在的问题,在研究了健康志愿者和患者药动学的基础上,调整了给药方案,进一步观察了疗效。调整后的给药方案,术后预防感染满意,减少了药量,减轻了患者肝肾负担,并节省了开支。

High performence chromatography for determining the levels of metronidazole and fluorescence polarization immunoassay for determining the levels of gentarnycin in serum and in tissue were established to evaluate the rationality of combined administration of these two drugs for perioperative prophylaxis of infection after abdominal surgery. Based on the results of pharmacokinetic studies performed on healthy volunteers and patients, the prophylactic scheme adopted in this hospital was readjusted. The new scheme increased prophylactic effect, reduced the dosages needed, ensured the salty as well as saved medical expense.