抗菌药临床静脉滴注间隔时间对治疗的影响

Impact on treatment between different medication time interval on antibacterial drugs

目的分析时间依赖性抗菌药物临床应用间隔时间及其改进措施。方法从我院2017年1月13日全部住院患者中选取使用时间依赖性抗菌药物患者294例作为研究对象,通过审查医嘱执行单对患者用药间隔时间进行分析并提出改进措施。结果时间依赖性抗菌药物主要以青霉素类与头孢菌素类为主;临床使用过程中静脉滴注时间间隔<8 h患者占25.42%,其每天2次静脉滴注间隔与定点静脉滴注间隔患者比例分别为80.27%与19.73%,且科室间执行情况有一定差别。结论时间依赖性抗菌药在实际使用中存在静脉滴注间隔时间不规范情况,应加强相关医护及科室人员的管理教育,做到规范、安全用药。

Objective To analysis the problem of medication time interval on antibacterial drugs and solve it. Methods 294 cases patients, treating by time dependent antimicrobial agents, who diagnosed from January 13,2017 and then find the problem through review orders list. Results Result showed that mostly using time interval on antibacterial drugs was penicillin and cephalosporin class. 25.42% time-dependent antibiotics of the bid infusion interval was lower than 8 h; the proportion of patients with nonstandard in fusion interval of bid（80.27% ） and regalar use（ 19.73% ）. There was some difference in the incidence of nonstandard infusion interval among different departments and wards. Conclusion Medical time-dependent antimicrobial agents in the actual use of intravenous drip interval is not standardized, should strengthen the relevant medical care and staff management education, so that norms, safe medication.