儿童急性一氧化碳中毒25例临床特点及迟发性脑病发生因素分析

Clinical analysis of 25 cases of children with acute carbon monoxide poisoning and study of high risk factors of delayed encephalopathy

目的分析儿童急性一氧化碳中毒的临床特点及迟发性脑病的发生因素。方法对25例儿童急性一氧化碳中毒患儿的临床资料进行回顾性分析,分析儿童急性一氧化碳中毒的临床特点及迟发性脑病高危因素。结果(1)25例患儿中位年龄9.48岁,出现迟发性脑病3例,年龄9~11岁。(2)未发生迟发性脑病与迟发性脑病患儿昏迷时间、首次高压氧治疗时间比较差异均无统计学意义(P>0.05),迟发性脑病患儿抽搐次数多于未发生迟发性脑病患儿(P<0.05)。(3)迟发性脑病患儿白细胞计数显著高于未发生迟发性脑病患儿(P<0.01)。结论儿童一氧化碳中毒后抽搐发生次数及WBC明显升高,头颅影像学及脑电图异常越明显,发生迟发性脑病危险性越大。

Objective To analyze the clinical characteristics of acute carbon monoxide poisoning in children and the risk factors of delayed encephalopathy. Methods The clinical data of 25 children with acute carbon monoxide poisoning were retrospectively analyzed, to explore the clinical characteristics of acute carbon monoxide poisoning in children and the risk factors of delayed encephalopathy. Results （ 1 ） The average age of 25 patients was 9.48 years old, there were 3 cases of delayed encephalopathy, aged 9 to 11 years old. （2） Coma time, first hyperbaric oxygen treatment time of no delayed encephalopathy and delayed encephalopathy, the difference was not statistically significant （ P 〉 0.05 ）. （ 3 ） The number of white blood cells in children with no delayed encephalopathy was significantly higher than that in children with delayed encephalopathy （P 〈 0.01 ）. Conclusion Children with carbon monoxide poisoning, the number of convulsions and white blood cell count were increased, head imaging and EEG abnormalities more obvious, the greater the risk of delayed encephalopathy.