南京原发性高血压住院患者慢性肾脏病的危险因素分析

Risk factor analysis of chronic kidney disease in hospitalized petients with essential hypertension in Nanjing

目的了解原发性高血压（EH）住院患者中慢性。肾脏病（CKD）的患病率，分析相关危险因素。方法回顾性分析2014年3月至2015年3月在南京医科大学第二附属医院住院确诊EH患者（1020例）的慢性肾脏疾病发病情况，对其危险因素分别进行单因素及多因素Logistic回归分析。结果（1）EH患者合并蛋白尿、eGFR下降及CKD的检出率分别为22．3％、13．3％、26．1％，男性和女性CKD的构成比为26．8％VS25．5％（P〉0．05）；（2）随着收缩压水平的升高（每升高20mmHg），CKD的构成比增加，差异有统计学意义（P〈0．05）；（3）EH合并CKD的危险因素依次为高尿酸血症（OR=2．682）、糖尿病史（OR=2．224）、收缩压≥140mmHg（OR=1．932）、年龄（OR=1．065）。结论高血压人群中CKD的检出率较高，更应注意控制好血压、血糖、血尿酸水平，以预防和延缓CKD的发生和发展。

Objective To investigate the prevalence of chronic kidney disease （CKD） in hospitalized patients with essential hypertension （EH） and analyze the related risk factors. Methods A retrospective analysis of chronic kidney disease and its influencing factors was taken from March 2014 to March 2015 in the Second Affiliated Hospital of Nanjing Medical University. People were diagnosed EH patients （ 1 020 cases）. Results （1） The detection rates of proteinuria, estimated glomerular filtration rate （eGFR） and CKD in patients with EH were 22. 3% ,13.3%, and 26. 1%, respectively. The ratio of CKD in male and female was 26. 8% vs 25.5% （P 〉 0. 05 ） ; （2） With the increase in systolic blood pressure levels （ as the systolic blood pressure increased 20 mmHg）, the constituent ratio of CKD increased with statistically significant difference （P 〈 0. 05 ） ; （3） The risk factors of essential hypertension complicated with chronic kidney disease were high uric acid, the history of diabetes, SBP≥ 140 mmHg and the age （OR = 2. 682, 2. 224, 1. 932, 1. 065）. Conclusions The detection rate of CKD in patients with hypertension in was high, and the blood pressure, blood glucose, and serum uric acid should be controlled to prevent and delay the occurrence and development of CKD.