胃癌患者血清FAS、CEA、CA72-4水平变化及其临床诊断价值

Changes of serum fatty acid synthase, carcinoembryonic antigen and carbohydrate antigen 72-4 in patients with gastric cancer and its clinical diagnostic value

目的分析胃癌患者血清脂肪酸合酶（FAS）、癌胚抗原（CEA）及糖类抗原72-4（CA72-4）水平变化及其临床诊断价值。方法选择2016年1月至2016年12月在医院接受治疗的胃癌患者45例、胃良性肿瘤患者45例，健康体检者45例，分别对三组FAS、CEA、CA72-4进行检测分析。结果胃癌组患者的FAS、CEA、CA72-4水平[（12．73±5．48）mg／L、（31．36±14．51）ng／ml、（39．32±18．76）U／ml]均高于胃良性肿瘤组[（2．26±1．15）mg／L、（3．24±1．47）ng／ml、（3．75±1．69）U／ml]和正常对照组[（1．83±0．92）mg／L、（2．71±1．54）ng／ml、（3．13±1．82）U／ml]，差异有统计学意义（P〈0．05）；胃癌组淋巴转移患者的FAS、CEA、CA72-4水平[（13．58±6．09）mg／L、（36．25±11．54）ng／ml、（41．31±13．67）U／ml]高于无淋巴转移的患者[（9．21±5．42）mg／L、（28．38±9．72）ng／ml、（26．75±11．86）U／ml]，差异有统计学意义（P〈0．05）；胃癌组FAS、CEA、CA72-4单独检测敏感度低于联合检测，胃癌组FAS、CEA、CA72-4单独检测特异度高于联合检测，差异有统计学意义（P〈0．05）；胃癌组淋巴结转移患者FAS、CEA、CA72-4单独检测敏感度均低于联合检测，FAS、CEA、CA72—4单独检测特异度高于联合检测，差异有统计学意义（P〈0．05）。结论FAS、CEA、CA72-4对胃癌诊断及判断淋巴结转移有一定参考意义。

Objective To analyze the changes of serum fatty acid synthase （FAS）, carcinoembryonic antigen （CEA） and carbohydrate antigen 72-4 （ CA72-4 ） in patients with gastric cancer and its clinical diagnostic value. Methods Forty five patients with gastric cancer and 45 patients with benign gastric cancer treated in our hospital from January 2016 to December 2016 were enrolled in this study. Forty five healthy subjects were enrolled in this study. The levels of FAS, CEA, and CA72-4 in three groups were analyzed. Results The levels of FAS, CEA, and CA72-4 in patients with gasttric cancer [ （ 12.73 ±5.48 ） mg/L, （31.36 ±14. 51 ）ng/ml, and （39.32± 18.76）U/ml] were significantly higher than those in benign gastric cancer group [ （2. 26 ± 1.15） rig/L, （3.24 ± 1.47） ng/ml, and （3.75 ±1.69） U/ml ] , and normal control group [ （1. 83 ±0. 92 ） mg/L, （2.71±1.54）ng/ml, and （3. 13±1.82）U/ml] （P〈0.05）. FAS, CEA, and CA72-4 levels in patients with lymph node metastasis of gastric cancer [ （ 13.58± 6. 09 ） mg/L, （6. 25 ±11.54）ng/ml, and （41.31 ± 13.67 ）U/ml ] were significantly higher than those without lymph node metastasis [（9.21±5.42）mg/L, （28.38 ±9.72）ng/ml, and （26.75 ±11.86）U/ml] （P〈0.05）. The sensitivity of FAS, CEA, and CA72-4 in patients with gastric cancer was significantly lower than that in combined detection, the specificity of FAS, CEA, and CA72-4 in patients with gastric cancer was significantly higher than that in combination test （P 〈 0. 05）. The sensitivity of FAS, CEA, and CA72-4 in patients with lymph node metastasis was significantly lower than that in combination test, and the specificity of FAS, CEA and CA72-4 was significantly higher than that of combined detection （P 〈 0. 05 ）. Conclusions FAS, CEA, and CA72-4 can be used as indicators of gastric cancer and diagnosis of lymph node metastasis. Combined detection of three indexes can improve the diagnostic sensitivity and have good clinical significance.