木果楝的化学成分研究

Chemical constituents of Xylocarpus granatum

目的对木果楝Xylocarpus granatum果实的化学成分进行研究。方法利用柱色谱、制备液相色谱、葡聚糖凝胶色谱等多种色谱方法分离纯化,用HR-ESI-MS、1H-NMR、13C-NMR、H-H COSY、HMQC和HMBC鉴定化合物结构。结果从木果楝果实95%乙醇提取物中分离得到17个化合物,分别鉴定为grantumin C(1)、cipadesin A(2)、xylocarpin G(3)、febrifugin(4)、tigloylseneganolide A(5)、khaysin T(6)、cipadesin(7)、granatumin B(8)、xyloccensin S(9)、granaxylocarpin C(10)、xylogranatin E2(11)、xyloccensin Q(12)、xyloccensin P(13)、cedrodorin(14)、xylorumphiins D(15)、hydroxydammarenone-II(16)、邻苯二甲酸双(2-乙基己基)酯(17)。结论化合物2、7、14、16、17为首次从该属植物中分离得到;化合物15为首次从该植物中分离得到。

Objective To study the chemical constituents of the fruits of Xylocarpus granatum. Methods The isolation and purification were carried out by silica gel column chromatography, Sephadex, preparative TLC, and preparative HPLC. The structures of the isolated compounds were identified with the help of HR-ESI-MS, 1H-NMR, 13C-NMR, H-H COSY, HMQC and HMBC techniques. Results Seventeen compounds were isolated and elucidated from the fruits of X. granatum, their structures were identified as： grantumin C（1）, cipadesin A（2）, xylocarpin G（3）, febrifugin（4）, tigloylseneganolide A（5）, khaysin T（6）, cipadesin（7）, granatumin B（8）, xyloccensin S（9）, granaxylocarpin C（10）, xylogranatin E2（11）, xyloccensin Q（12）, xyloccensin P（13）, cedrodorin（14）, xylorumphiins D（15）, hydroxydammarenone-II（16）, and bis（2-ethylhexyl） phthalate（17）. ConclusionCompounds 2, 7, 14, 16 and 17 are isolated from the plants of Xylocarpus Koenig for the first time. Compound 15 is obtained from X. granatum for the first time.