IL-10基因-1082A>G位点多态性与非霍奇金淋巴瘤易感性的Meta分析

Interleukin-10 gene-1082A>G polymorphism and non-Hodgkin lymphoma susceptibility:a Meta-analysis

目的:用Meta分析法评价IL-10基因-1082A>G位点的多态性与非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)易感性的相关性。方法:利用计算机检索Pub Med、EMBASE、Web of Science、中国生物医学文献数据库、中文科技期刊全文数据库、中国期刊全文数据库和万方数据库,检索日期自各数据库建库到2017年1月止,全面检索IL-10基因-1082 A>G位点的多态性与NHL易感性的病例对照研究文献,采用STATA 12.0统计软件进行Meta分析。结果:最终纳入16篇病例对照研究文献进行Meta分析,共计4 718例NHL患者和3 877例健康对照人员。分析结果显示,IL-10基因-1082A>G位点在等位基因模型(A vs G:OR=1.12,95%CI=1.04~1.21)、共显性模型(AA vs AG:OR=1.27,95%CI=1.06~1.52)、相加模型(AA vs GG:OR=1.22,95%CI=1.06~1.40)和显性模型(AA vs AG+GG:OR=1.29,95%CI=1.08~1.53)下与NHL易感性有关;而在隐性模型(GG vs AA+AG:OR=1.11,95%CI=0.92~1.34)与NHL易感性无关。结论:IL-10基因-1082 A>G位点多态性可能与NHL易感性相关。

Objective： To assess the association between interleukin-10 （IL-10） gene- 1082A〉G polymorphism and non-Hodgkin lymphoma （NHL） susceptibility using Meta-analysis. Methods： Case-control studies about IL-IO gene- 1082A〉G polymorphism and NHL susceptibility were searched in PubMed, EMBASE, Web of Science, Chinese Biomedical Literature Database, Chinese Science and Technology Academic Journal, Chinese Journal Full- text Database and Wanfang Database from their inception toJanuary 2017. Meta-analysis was performed using STATA 12.0 software. Results： A total of 16 case-control studies were included in this Meta-analysis, including 4 718 cases and 3 877 controls. There was association between IL-IO gene -1082A〉G polymorphism and NHL susceptibility inallele genetic model （Avs G： OR=l.12, 95%CI=1.04- 1.21）, codominant model （AA vs AG： OR=1.27, 95% CI=1.06-1.52） , additive model （AAvs GG： 0R=1.22, 95%CI=1.06-1.40） and dominant model （AA vs AG＋GG： OR= 1.29, 95%CI=1.08-1.53）, but no association with NHL susceptibility in recessive model （GG vs AA＋ AG：OR=1. 11, 95%CI=0.92- 1.34）. Conclusion： IL-10 gene - 1082A 〉 G polymorphismmay be associated with NHL Susceptibility.