乙醇封管对导管相关性血流感染预防效果的Meta分析

Effect of ethanol lock on prevention of catheter-related bloodstream infections:a meta-analysis

目的评价乙醇封管对导管相关性血流感染的预防效果。方法计算机检索PubMed、The Cochrane Library、EMbase、CBM、CNKI数据库从2007年1月至2017年7月的相关文献,纳入乙醇封管用于预防导管相关性血流感染的随机对照试验,由2名研究者独立筛选文献、提取资料和评价纳入研究的方法学质量。结果共纳入9篇文献研究,2443例患者。结果显示,乙醇封管组CRBSI发生率低于对照组[RR=0.57,95%CI(0.39,0.83),P=0.003],而两组在导管出口部位感染、不良反应、血栓和导管功能不良方面没有统计学差异。结论乙醇封管能够减少导管相关性血流感染的发生;受所纳入研究质量的限制,尚需要开展更多高质量研究予以验证。

OBJECTIVE To evaluate the effect of ethanol lock on prevention of catheter-related bloodstream infections.METHODS The related literatures that were published from Jan 2007 to Jul 2017 were retrieved from the databases,including PubMed,The Cochrane Library,EMbase,CBM and CNKI and were included in the randomized controlled trial for the use of ethanol lock in prevention of catheter-related bloodstream infections,the literatures were screened independently by two reviewers,the data were extracted,and the methodology quality of the included studies was evaluated.RESULTS Totally 9 literatures were included,involving 2443 patients.The result indicated that the incidence rate of CRBSI of the ethanol lock group was lower than that of the control group[RR=0.57,95% CI（0.39,0.83）,P=0.003].However,there was no significant difference in the incidence of catheter outlet site infections,adverse reactions,thrombus,or adverse catheter function between the two groups.CONCLUSIONThe ethanol lock may reduce the incidence of catheter-related bloodstream infections.Owing to the restriction of quality of the included studies,more high-quality studies should be conducted to validate.