基于复杂网络等方法的十九畏人参-五灵脂同方配伍探析

Research on compatibility of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung based on complex network analysis

为探讨十九畏中人参-五灵脂同方配伍应用特点以及古今配伍的差异,整理1949—2016年现代文献中人参-五灵脂同方配伍的应用,运用无尺度复杂网络等数据挖掘方法对其进行分析,并与历代人参-五灵脂同方方剂对照。结果表明十九畏中人参-五灵脂这一组药物不是绝对的配伍禁忌。1949—2016年人参-五灵脂同方应用报道中人参-五灵脂同方主要应用于治疗气虚血瘀证的恶性肿瘤、冠心病等;方中常配伍益气补血、活血止痛功效的药物,复杂网络关系显示与人参-五灵脂联系最为密切的药物为甘草、当归、黄芪、蒲黄、丹参,其次是白芍、白术、桃仁、茯苓等,外围还有红花、三七、香附、柴胡等;核心药对为人参-甘草、五灵脂-甘草、人参-当归、五灵脂-当归、人参-黄芪、五灵脂-黄芪等,人参-五灵脂-甘草,人参-五灵脂-当归,人参-五灵脂-黄芪,人参-五灵脂-蒲黄等药组支持度较高。古今人参-五灵脂同方方剂中的主要药物配伍存在差异,现代方剂中频繁使用三七、蒲黄、丹参、黄芪等,古代应用较少,古今比较显示现代更为注重配伍活血益气药。

Abstract：The applications of prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung in contemporary literatures from 1949 to 2016 are compiled and the data mining techniques containing scale-free complex network method are utilized to explore its practical characteristics, with comparison between modern and ancient ones. The results indicate that malignant neoplasms, coronary heart disease which present Qi deficiency and blood stasis type are the main diseases treated by prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung according to the reports during 1949 to 2016. The complex network connection shows that Glycyrrhizae Radixet Rhizoma, Angelicae Sinensis Radix, Astragali Radix, Typhae Pollen, Salviae Miltiorrhizae Radix et Rhizoma are the primary drugs related to Ginseng Radix et Rhizoma and Trogopterus Dung. The next are Paeoniae Radix Alba, Atractylodis Macrocephalae Rhizoma, Persicae Semen, Foria, et al. Carthami Flos, Notoginseng Radix et Rhizoma, Cyperi Rhizoma, Bupleuri Radix are the peripheral ones. Also, Ginseng Radix et Rhizoma-Glycyrrhizae Radixet Rhizoma, Trogopterus Dung-Glycyrrhizae Radixet Rhizoma, Ginseng Radix et Rhizoma-Angelicae Sinensis Radix, Trogopterus Dung-Angelicae Sinensis Radix, Ginseng Radix et Rhizoma-Astragali Radix, Trogopterus Dung-Astragali Radix are the main paired drugs. The paired drugs including Ginseng Radix et Rhizoma-Trogopterus Dung-Glycyrrhizae Radixet Rhizoma, Ginseng Radix et Rhizoma-Trogopterus Dung-Angelicae Sinensis Radix, Ginseng Radix et Rhizoma-Trogopterus Dung-Astragali Radix, Ginseng Radix et Rhizoma-Trogopterus Dung-Typhae Pollen have a higher support degree. The main compatible drugs are different in ancient and modern prescriptions including Ginseng Radix et Rhizoma and Trogopterus Dung. Notoginseng Radix et Rhizoma, Typhae Pollen, Salviae Miltiorrhizae Radix et Rhizoma, Astragali Radix are utilized frequently in modern prescriptions while less used in ancient ones. It is also shown that more attentions are paid to the drugs contributing to invigorating Qi and promoting blood circulation in modern times with comparative results between modern and ancient prescriptions.