异甘草素共晶的热力学研究

Thermodynamics of isoliquiritigenin cocrystals

目的:探究异甘草素共晶在异丙醇溶剂中的形成热力学。方法:以异甘草素-烟酰胺及异甘草素-异烟酰胺共晶为模型,通过测定303K下异甘草素、烟酰胺及异烟酰胺在异丙醇中的溶解度,计算溶剂中共晶的溶度积和络合常数,并绘制出异甘草素-烟酰胺及异甘草素-异烟酰胺三元相图。结果:2种异甘草素共晶在异丙醇中均符合1∶1溶液络合模型,但2种共晶体系在该条件下的三元相图有较大差异,异甘草素-烟酰胺共晶三相图的共晶区域偏离化学计量比线。常规方法不利于异甘草素共晶的形成。结论:共晶制备方法的优选具有参考意义。

Objective： To investigate the formation thermodynamics of isoliquiritigenin cocrystals.Methods： The cocrystals of isoliquiritigenin（ ISL）-nicotinamide（ NIC） and isoliquiritigenin（ ISL）-isonicotinamide（ INM） were used as the models for studying the solubility of ISL,NIC and INM in isopropanol（ IPR） at 303 K. The solubility product（ K_（sp）） and complexation constant（ K_（11）） of the cocrystals were measured and the ternary phase diagrams（ TPDs） were established in isopropanol at 303 K. Results： The solubility data showed that the ISL-NICIPR and ISL-INM-IPR systems matched 1∶ 1 complexation mechanism. However,these two cocrystal systems＇ TPDs were greatly different in the same condition. The cocrystallization zone of ISL-NIC system was far away from stoichiometric line. Conventional method is disadvantageous to the formation of cocrystals. Conclusion： This study has important significance on the selection of optimal synthetic methods of cocrystals.