通络生骨方治疗激素性股骨头坏死的临床研究

Clinical research of Tongluo Shenggu recipe in treatment of hormone femoral head necrosis

目的探讨通络生骨方治疗激素性股骨头坏死的临床疗效。方法选取本院2014年8月~2016年8月诊治的激素性股骨头坏死患者240例,采用随机数字表法分为两组,对照组患者120例采用健骨生丸治疗,观察组患者120例采用通络生骨方治疗,于治疗前后给予患者临床指标检测、Harris评分,比较两组患者临床疗效、不良反应。结果治疗后,两组患者临床指标(全血黏度高切、全血黏度低切、血细胞比容、血浆黏度)降低(P<0.05)。两组患者Harris评分(疼痛程度、关节畸形、关节活动度、关节功能、总分)增加(P<0.05)。观察组患者临床指标(全血黏度高切、全血黏度低切、血细胞比容、血浆黏度)、不良反应发生率低于对照组(P<0.05)。观察组患者Harris评分(疼痛程度、关节畸形、关节活动度、关节功能、总分)、治疗优良率高于对照组(P<0.05)。结论通络生骨方治疗激素性股骨头坏死的疗效显著,可改善患者血液流变学指征和关节功能。

Objective To investigate clinical effect of Tongluo Shenggu recipe in treatment for hormone femoral head necrosis. Methods 240 patients with hormone femoral head necrosis in our hospital from August 2014 to August 2016were selected and divided into two groups by random number table method.120 patients treated Jiangusheng pill were as control group. 120 patients treated Tongluo Shenggu recipe were as observation group. Clinical index, Harris score were detected before and after treatment. Clinical efficacy, adverse reactions were compared between two groups. Results After treatment, clinical parameters （whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, plasma viscosity） decreased in two groups（P 〈 0.05）.Harris score （pain degree, joint deformity, joint mobility, joint function, total score） increased in two groups（P 〈 0.05）. Clinical parameters （whole blood high shear viscosity, whole blood low shear viscosity, hematocrit, plasma viscosity）, incidence of adverse reactions in observation group were lower than those in control group （P 〈 0.05）. Harris score （pain degree, joint deformity, joint mobility, joint function, total score）,treatmentexcellent rate in observation group were higher than those in control group （P 〈 0.05）. Conclusion Tongluo Shenggu recipe has significant effect in treatment for hormone femoral head necrosis, It can improve hemorheology indication and joint function.