伊伐布雷定治疗老年心力衰竭患者的疗效观察

Curative effect observation of ivabradine in the treatment of senile heart failure

目的分析伊伐布雷定治疗老年心力衰竭患者的临床疗效。方法分析我院2014年2月~2016年3月期间住院治疗的88例老年慢性心衰患者,随机分为对照组和观察组,均44例,观察组采取伊伐布雷定治疗,对照组接受常规治疗,分析治疗3个月后两组心率、血浆N末端B型利钠肽原水平、6min步行距离、左心室射血分数、不良反应等情况。结果治疗3个月后,和对照组比较,观察组在心率、血浆、明尼苏达心衰量表评分6min步行距离、左心室射血分数等方面的差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05);观察组NT-ProBNP含量明显低于对照哦组,差异有统计学意义(P<0.05)。结论 NT-ProBNP水平被认为是心力衰竭患者的客观指标,研究采用伊伐布雷定治疗老年心力衰竭,NT-ProBNP水平及其他指标差异显著,提示该药物治疗效果显著,安全性高。

Objective To analyze the clinical efficacy of ivabradine treatment in elderly patients with chronic heart failure. Methods 88 cases of elderly patients with chronic heart failure cured in our hospital from February 2014 to March 2016 during the period of hospitalization were analyzed.They were randomly divided into control group and observation group with 44 cases in each. Patients in observation group were treated with ivabradine treatment, and patients in the control group were with routine treatment. Results After 3 months of treatment, compared with control group, the observation group in plasma, heart rate, heart failure score of Minnesota 6min walking distance difference, left ventrieular ejection fraction and other aspects of the statistical significance （P 〈 0.05）, and the observation group with less adverse reaction. After 3 months, the heart rate, plasma N terminal, type B natriuretie peptide, 6miin walking distance, left ventricular ejection fraction, adverse reactions of the two group were analyzed. Conclusion After 3 months of treatment, compared with control group, the difference in heart rate, plasma, Minnesota heart failure scale score, 6min walking distance, left ventricular ejection fraction between the observation group and the observation group were statistically significant （P 〈 0.05）. The incidence of adverse reactions in observation group was lower than that in control group, the difference was significant （P 〈 0.05）. The content of NT-ProBNP in the observation group was significantly lower than that in the control group, the difference was statistically significant（P 〈 0.05）. Conclusion NT-ProBNP levels are considered an objective measure of heart failure. This research adopts the ivabradine treatment of senile heart failure. NT-ProBNP levels and other indicators are significantly different, it suggests that the drug treatment effect is remarkable, safety is high.