妊娠合并甲状腺功能减退症患者的临床诊治效果分析

Clinical analysis of the diagnosis and treatment of hypothyroidism in pregnancy

目的分析妊娠合并甲状腺功能减退症患者的诊断方法和治疗效果。方法对我院2014年2月~2016年8月收治的120例妊娠合并甲状腺功能减退症患者的临床资料进行回顾分析,根据甲状腺功能恢复状况分为对照组和观察组,比较两组患者的合并症及妊娠结局,并测定患者治疗前后的血脂水平。结果本组患者治疗前后血脂水平的比较差异有统计学意义(P<0.05)。观察组胎儿宫内窘迫、妊娠期高血压、肝内胆汁淤积症、糖代谢异常发生率为3.75%、2.50%、5.00%、2.50%,均低于对照组的15.00%、12.50%、17.50%、15.00%,差异有统计学意义(P<0.05);观察组新生儿窒息、死胎、早产、胎儿畸形发生率为2.50%、0、1.25%、1.25%,均低于对照组的17.50%、10.00%、10.00%、12.50%,差异有统计学意义(P<0.05)。结论及时采取有效措施进行诊断和治疗,促进患者甲状腺功能恢复,对降低血脂水平、减少妊娠合并症、改善妊娠结局具有重要意义。

Objective To analyze the diagnosis and treatment of hypothyroidism in pregnancy. Methods Clinical data of 120 cases of pregnancy with hypothyroidism from February 2014 to August 2016 in our hospital were retrospectively analyzed. They were divided into control group and observation group according to the recovery of thyroid function. The complication and pregnancy outcome of the two groups were compared, and the blood lipid levels before and after treatment were measured. Results The blood lipid levels of the patients before and after treatment were statistically significant （P 〈 0.05）. The incidence of fetal distress, pregnancy induced hypertension, intrahepatic cholestasis, and abnormal glucose metabolism were 3.75%, 2.50%, 5.00% and 2.50% respectively, which＇were lower than 15%, 12.50%, 17.50% and 15% in the control group, the difference was statistically significant （P 〈 0.05）; The incidence of neonatal asphyxia, stillbirth, premature birth and fetal malformation in the observation group was 2.50%, O, 1.25% and 1.25% respectively, which were lower than 17.50%, 10.00%, 10.00% and 12.50% in the control group, the difference was statistically significant （P 〈 0.05）. Conclusion It is important to take effective measures for diagnosis and treatment, to promote the recovery of thyroid function, to reduce the blood lipid level, to reduce the complication of pregnancy and to improve the pregnancy outcome.