奥曲肽联合奥美拉唑治疗上消化道出血对止血率和止血时间的影响

Influence of octreotide combined with omeprazole on hemostasis rate and hemostasis time in patients with upper gastrointestinal bleeding

目的探讨奥曲肽联合奥美拉唑治疗上消化道出血对止血率和止血时间的影响。方法选取2013年5月~2017年4月我院接受诊治的60例上消化道出血患者,随机分为对照组与观察组,每组30例。对照组选用注射用奥美拉唑进行治疗,观察组以注射用奥美拉唑联合醋酸奥曲肽注射液进行治疗,观察并记录两组患者24h及48h止血率、再出血率、平均止血时间、不良反应发生情况。结果观察组总有效率为93.33%,显著高于对照组的73.33%,差异具有统计学意义(P<0.05);观察组24h止血率为60.00%、48h止血率为86.67%,分别高于对照组的46.67%和70.00%,观察组再出血率为6.67%,低于对照组的23.33%,但差异均无统计学意义(P>0.05);观察组平均出血时间为(20.86±4.26)h,明显低于对照组的(29.04±6.14)h,差异具有统计学意义(P<0.05);两组患者均未出现明显不良反应。结论奥美拉唑与奥曲肽联合治疗上消化道出血的临床效果明显,患者再出血率降低、平均出血时间缩短,且无不良反应,具有积极的临床意义,值得推广。

Objective To investigate the influence of octreotide combined with omeprazole on the hemostasis rate and the time of bleeding in patients with upper gastrointestinal bleeding. Methods 60 patients with upper gastrointestinal bleeding who diagnosed and treated in our hospital from May 2013 to April 2017 were selected and randomly divided into the control group and the observation group, 30 cases in each group. The patients of control group were treated with omeprazole injection therapy, the patients of observation group were treated with omeprazole combined with octreotide acetate injection. The bleeding rate, re-bleeding rate, average hemostasis time and the incidence of adverse reactions of patients in two groups after 24h and 48h were observed and recorded. Results The total effective rate of the observation group was 93.33%, significantly higher than 73.33% of the control group, the difference was statistically significant （P 〈 0.05）. After 24h, the hemostasis rate of the observation group was 60%, and after 48h the hemostasis rate of the observation group was 86.67%, respectively, higher than 46.67% and 70% of the control group. The re-bleeding rate of the observation group was 6.67%, lower than 23.33% of the control group, but there was no statistically sigrtificant difference （P 〉 0.05）. The average bleeding time of the observation group was （20.86 ± 4.26） h, significantly lower than （29.04 ± 6.14） h of the control group, the difference was statistically significant （P 〈 0.05）. There were no obvious adverse reactions in two groups. Conclusion The clinical effect of omeprazole combined with octreotide in treating upper gastrointestinal hemorrhage is obvious, which reduces the re- bleeding rate of patients, shortens the average time and has no adverse reactions. It has positive clinical significance and is worthy of promotion.