CRP、TNF-α和血脂在冠心病不稳定型心绞痛患者中的表达

Expression of CRP, TNF-α and blood lipid in the patients with coronary heart disease complicated with unstable angina

目的研究冠心病不稳定型心绞痛患者血清中CRP、TNF-α和血脂的表达水平,探讨CRP、TNF-α、血脂三者与冠心病不稳定型心绞痛之间的关系。方法收集2015年8月~2016年9月本院收治的46例不稳定型心绞痛患者和40例稳定型心绞痛患者的临床资料进行分析;并分别测定两组患者和健康对照人群血清中CRP、TNF-α和血脂的表达水平。结果 ELISA实验结果表明,相比对照组人群,不稳定型心绞痛患者血清中CRP和TNF-α表达水平明显增加,LDL-C和TG含量也有所增加,与对照组比较,差异均有统计学意义(P<0.05);稳定型心绞痛患者血清中CRP、LDL-C和TG含量有所增加,且差异具有统计学意义(P<0.05),而TNF-α、HDL-C和TC水平与健康对照人群比较,差异无统计学意义(P>0.05)。结论 CRP、TNF-α和血脂可能与冠心病不稳定型心绞痛的发生发展密切相关,检测冠心病不稳定型心绞痛患者血清中CRP、TNF-α和血脂含量,对了解患者体内免疫状态、临床诊断和预后有重要意义。

Objective To study the expression levels of serum CRP, TNF-α and blood lipids in the patients with coronary heart disease complicated with unstable angina, and to investigate the relationship between the three factors of CRP, TNF-α and blood lipid and coronary heart disease complicated with unstable angina. Methods The clinical data of 46 patients with unstable angina and 40 patients with stable angina who were admitted to our hospital from August 2015 to September 2016 were collected, and an overall analysis was made; the expression levels of serum CRP, TNF-α and blood lipids were measured in the patients with two types of diseases and healthy controls. Results The results of ELISA showed that the expression levels of serum CRP and TNF-α in the patients with unstable angina pectoris were significantly increased compared with the control group, and the LDL-C and TG levels were also increased. Compared with the control group, there were significant differences（P〈0.05）; the levels of serum CRP, LDL-C and TG in the patients with stable angina were increased, and the difference was statistically significant（P〈0.05）. However, TNF-α, HDL-C and TC levels did not change significantly compared with those in the healthy controls, and the difference was not statistically significant（P〉0.05）. Conclusion CRP, TNF-α and blood lipids may be closely related to the occurrence and development of coronary heart disease complicated with unstable angina. Detection of serum CRP, TNF-α and blood lipids levels in the patients with coronary heart disease complicated with unstable angina is of great significance to understand the immune status, clinical diagnosis and prognosis of the patients.