补肾壮骨方治疗强直性脊柱炎46例临床观察

Clinical observation of 46 cases of Bushen Zhuanggu Decoction in treating ankylosing spondylitis

目的:通过对补肾壮骨方临床疗效的观察,进一步探讨其治疗强直性脊柱炎的作用机制。方法:应用随机数字表把纳入的92例患者随机分为治疗组、对照组,两组各46例,对照组予柳氮磺吡片,每次口服750mg,bid;治疗组在对照组基础上联合补肾壮骨汤,每日一剂。结果:治疗组、对照组的总有效率分别是89.13%和65.22%;治疗组明显优于对照组(P<0.05)。两组主要症状及体征(胸廓活动度、疼痛、指地距、Schoher试验、脊柱活动度)显著改善(P<0.05),且治疗组优于对照组(P<0.05)。结论:补肾壮骨方治疗肝肾不足、筋脉瘀滞型强直性脊柱炎疗效显著,并能提高患者生活质量,值得临床推广。

Objective：To observe the clinical curative effect of Bushen Zhuanggu decoction,to further explore the mechanism of treatment of ankylosing spondylitis.Methods：Using the random number table included in the 92 patients were randomly divided into treatment group and control group, two of 46 cases in each group.The control group received sulfasalazine pyridine,750 mg orally,bid;treatment group in the control group based on the combined with Bushenzhuanggu decoction,one dose daily.Results：The total effective rate of the treatment group and the control group was 89.13% and 65.22% respectively,and the treatment group was significantly better than that of the control group（P0.05）.The main symptoms and signs（chest mobility, pain,finger distance,Schoher test and spinal mobility） of the two groups were significantly improved（P0.05）,and the treatment group was better than that of the control group（P0.05）.Conclusion：Bushen Zhuanggu Decoction in the treatment of liver and kidney deficiency,blood stasis syndrome curative effect of ankylosing spondylitis significantly,and can improve the quality of life of patients,is worthy of promotion.